Intima-media thickness in women with borderline personality disorder

Patients with borderline personality disorder (BPD) may have a higher risk of developing cardiovascular disease caused by altered endocrine, metabolic, and inflammatory parameters. Increased intima-media thickness (IMT) is considered an early marker of atherosclerosis and is associated with most car...

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Bibliographic Details
Published in:Psychosomatic medicine 2011-09, Vol.73 (7), p.627-632
Main Authors: Greggersen, Wiebke, Rudolf, Sebastian, Brandt, Peer-Willem, Schulz, Ellen, Fassbinder, Eva, Willenborg, Bastian, Kahl, Kai G, Bergmann-Koester, Claudia, Stoeckelhuber, Beate M, Hohagen, Fritz, Schweiger, Ulrich
Format: Article
Language:English
Subjects:
Adolescent
Adult
Atherosclerosis
Atherosclerosis - complications
Atherosclerosis - diagnostic imaging
Atherosclerosis - psychology
Borderline personality disorder
Borderline Personality Disorder - complications
Cardiovascular disease
Cardiovascular diseases
Carotid Arteries - diagnostic imaging
Case-Control Studies
Deviation
Female
Humans
Linear Models
Middle Aged
Personality disorders
Physical activity
Psychiatric Status Rating Scales
Risk Factors
Selfreport
Tunica Intima - diagnostic imaging
Tunica Media - diagnostic imaging
Ultrasonography
Women
Womens health
Young Adult
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Summary:Patients with borderline personality disorder (BPD) may have a higher risk of developing cardiovascular disease caused by altered endocrine, metabolic, and inflammatory parameters. Increased intima-media thickness (IMT) is considered an early marker of atherosclerosis and is associated with most cardiovascular risk factors. The mean IMT of the common carotid arteries was assessed by B-mode ultrasound in 47 women with BPD and 28 age-matched healthy women. Mean (standard deviation) age for BPD participants was 31.2 (10.4) years and 31.9 (11.0) years for the comparison group. In addition, Adult Treatment Panel III criteria for metabolic syndrome and markers of inflammation were measured. The patients were characterized by applying DSM-IV criteria and obtaining self-reports of adverse childhood experiences. Women with BPD had a significantly higher IMT than healthy women (mean [standard deviation] = 0.41 [0.11] versus 0.34 [0.11] mm, p = .02). In linear regression analysis, IMT was significantly associated with BPD even when adjusting for body mass index (β = 0.27, p = .04) and physical activity (β = 0.29, p = .02). The data suggest that women with BPD are at increased risk of developing subsequent cardiovascular disease.
ISSN:0033-3174
1534-7796
DOI:10.1097/PSY.0b013e3182231fe2