Is Autoimmunity to CCR5 an Escape from the Intrusive HIV?

Albeit strictly controlled in immune function and in ontogenesis, autoimmunity may develop upon inflammatory response to pathogens, with harmful consequences to host. Findings of autoimmune-like responses, observed in HIVinfected patients, might play a key role in modulating the natural history of t...

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Bibliographic Details
Published in:The Open autoimmunity journal 2010-01, Vol.2, p.117-126
Main Authors: Russo, Silvia, Diomede, Lorenzo, Lopalco, Lucia
Format: Article
Language:English
Subjects:
Human immunodeficiency virus
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Summary:Albeit strictly controlled in immune function and in ontogenesis, autoimmunity may develop upon inflammatory response to pathogens, with harmful consequences to host. Findings of autoimmune-like responses, observed in HIVinfected patients, might play a key role in modulating the natural history of the infection and/or could even confer protection to HIV. This paper will focus on a special class of auto-antibodies observed in HIV exposure, anti-CCR5 IgG and IgA and on their protective potential.
ISSN:1876-8946
1876-8946
DOI:10.2174/1876894601002010117