The use of a formal sensitivity analysis on epidemic models with immune protection from maternally acquired antibodies

Abstract This paper considers the outcome of a formal sensitivity analysis on a series of epidemic model structures developed to study the population level effects of maternal antibodies. The analysis is used to compare the potential influence of maternally acquired immunity on various age and time...

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Bibliographic Details
Published in:Computer methods and programs in biomedicine 2011-11, Vol.104 (2), p.37-49
Main Authors: Chapman, J.D, Chappell, M.J, Evans, N.D
Format: Article
Language:English
Subjects:
Age
Age dependency
Antibodies
Computer programs
Computer simulation
Epidemics
Immunity, Maternally-Acquired
Internal Medicine
Maternal antibodies
Mathematical models
Models, Theoretical
Other
PDE systems
Seasons
Sensitivity analysis
Serological survey
SIR epidemic models
Time series
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Summary:Abstract This paper considers the outcome of a formal sensitivity analysis on a series of epidemic model structures developed to study the population level effects of maternal antibodies. The analysis is used to compare the potential influence of maternally acquired immunity on various age and time domain observations of infection and serology, with and without seasonality. The results of the analysis indicate that time series observations are largely insensitive to variations in the average duration of this protection, and that age related empirical data are likely to be most appropriate for estimating these characteristics.
ISSN:0169-2607
1872-7565
DOI:10.1016/j.cmpb.2010.08.019