Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains

Objectives Gonorrhoea remains a global public health problem and the treatment options are diminishing through the emergence of gonococci resistant to most antimicrobials. Previous in vitro studies have indicated a role for Neisseria gonorrhoeae pilQ alterations in conferring resistance to antimicro...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2010-12, Vol.65 (12), p.2543-2547
Main Authors: Whiley, David M., Jacobsson, Susanne, Tapsall, John W., Nissen, Michael D., Sloots, Theo P., Unemo, Magnus
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino acids
Anti-Bacterial Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
antimicrobial resistance
Bacteria
Bacterial diseases
Bacterial diseases of the genital system
Biological and medical sciences
Cefixime - pharmacology
Ceftriaxone - pharmacology
Cephalosporin Resistance - genetics
Drug resistance
Epidemiology. Vaccinations
extended-spectrum cephalosporins
Fimbriae Proteins - genetics
General aspects
Genes
Gonorrhea
Gonorrhea - microbiology
gonorrhoea
Human bacterial diseases
Humans
Infectious diseases
Medical sciences
Microbial Sensitivity Tests
Molecular Sequence Data
Mutation
Neisseria gonorrhoeae
Neisseria gonorrhoeae - drug effects
Neisseria gonorrhoeae - genetics
penA
Pharmacology. Drug treatments
Polymorphism
Public health
third generation
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Summary:Objectives Gonorrhoea remains a global public health problem and the treatment options are diminishing through the emergence of gonococci resistant to most antimicrobials. Previous in vitro studies have indicated a role for Neisseria gonorrhoeae pilQ alterations in conferring resistance to antimicrobials, including penicillin. In this study, we investigated whether pilQ polymorphisms were associated with decreased susceptibility to extended-spectrum cephalosporins (ESCs) in clinical gonococcal strains. Methods Full-length pilQ nucleotide and PilQ amino acid sequences from geographically and temporally diverse gonococcal clinical isolates (n = 63), including the 2008 WHO reference strains, representing a range of ceftriaxone and cefixime MICs (≤0.008–0.25 and
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkq377