Monocyte and T-Cell Responses to Exercise Training in Elderly Subjects

• Published in: Journal of strength and conditioning research 2011-09, Vol.25 (9), p.2565-2572
• Main Authors: Shimizu, Kazuhiro, Suzuki, Natsumi, Imai, Tomoko, Aizawa, Katsuji, Nanba, Hideyuki, Hanaoka, Yukichi, Kuno, Shinya, Mesaki, Noboru, Kono, Ichiro, Akama, Takao
• Format: Article
• Language: English
• Subjects: Aged; Antigens, CD - blood; Antigens, CD - immunology; Female; Gene expression; Hip - physiology; Humans; Immune system; Immunity, Cellular - immunology; Leg - physiology; Leukocyte Count; Leukocytes; Lymphocyte Activation - immunology; Male; Middle Aged; Monocytes - immunology; Muscle Stretching Exercises; Older people; Physical Endurance - immunology; Physical Endurance - physiology; Resistance Training; Sports training; T cell receptors; T-Lymphocytes - immunology; Toll-Like Receptor 4 - blood; Toll-Like Receptor 4 - immunology
• ISSN: 1064-8011; 1533-4287
• DOI: 10.1519/JSC.0b013e3181fc5e67

Shimizu, K, Suzuki, N, Imai, T, Aizawa, K, Nanba, H, Hanaoka, Y, Kuno, S, Mesaki, N, Kono, I, and Akama, T. Monocyte and T-cell responses to exercise training in elderly subjects. J Strength Cond Res 25(9)2565-2572, 2011—The purpose of this study was to examine the effects of exercise training on age-related impairment of immune parameters related to T-cell activation in elderly individuals. Twenty-four elderly subjects were assigned to an exercise training group (EXC3 men, 9 women; age 61-76 years) or a nonexercise control group (CON4 men, 8 women; age 62-79 years). Subjects in EXC participated in exercise sessions 2 d·wk for 12 weeks. The training session included stretching and endurance exercise (10 minutes), resistance training comprised leg extension, leg press, hip abduction, and hip adduction using exercise machine and each subjectʼs body weight. Subjects in CON maintained their normal physical activity levels during the study period. Blood samples were collected before and after the training period. Samples were measured for the numbers of leukocytes, lymphocytes, and monocytes, and for CD3, CD4, CD8, CD28CD4, CD28CD8, TRL-4CD14, and CD80CD14 cells. The number of leukocytes, lymphocytes, monocytes, CD3, CD4, and CD8 cells did not change after 12 weeks in either EXC or CON. The number of CD28CD8 cells increased significantly after training in EXC (p ≤ 0.05), although CON showed no significant change. In the EXC group, CD80CD14 cell counts were significantly higher after training (p ≤ 0.05), but the TLR-4CD14 cell counts were unchanged. In the CON group, no significant alteration existed in TLR-4CD14 and CD80CD14 cell numbers. In conclusion, exercise training in elderly people is associated with increased CD28-expressing Tc cells and CD80-expressing monocytes. Therefore, exercise training might upregulate monocyte and T-cell-mediated immunity in elderly people.