Loading…
Determinants of plasma brain natriuretic peptide levels in untreated hypertensive patients
Background Plasma brain natriuretic peptide (BNP) level is elevated in patients with left ventricular (LV) hypertrophy reflecting not only altered LV geometry but LV systolic and/or diastolic dysfunction. However, the values and limitations of BNP measurements are unclear in patients with untreated...
Saved in:
| Published in: | Journal of echocardiography 2011-09, Vol.9 (3), p.103-108 |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c471t-e230f222e99686f5aebbd79354602ae3fed1a6277202a96c64e3522f2b2c92503 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c471t-e230f222e99686f5aebbd79354602ae3fed1a6277202a96c64e3522f2b2c92503 |
| container_end_page | 108 |
| container_issue | 3 |
| container_start_page | 103 |
| container_title | Journal of echocardiography |
| container_volume | 9 |
| creator | Goda, Akiko Nakao, Shinji Tsujino, Takeshi Yuba, Masao Otsuka, Misato Matsumoto, Mika Yoshida, Chikako Naito, Yoshiro Lee-Kawabata, Masaaki Ohyanagi, Mitsumasa Masuyama, Tohru |
| description | Background
Plasma brain natriuretic peptide (BNP) level is elevated in patients with left ventricular (LV) hypertrophy reflecting not only altered LV geometry but LV systolic and/or diastolic dysfunction. However, the values and limitations of BNP measurements are unclear in patients with untreated hypertension. In this study, plasma BNP level was compared with LV geometric and functional characteristics in patients with untreated hypertension.
Methods
Plasma BNP level was measured in 115 patients with untreated hypertension (72 males, 43 females, aged 60 ± 12 years). Routine echo parameters of LV geometry and LV systolic and diastolic performance were also determined.
Results
LV ejection fraction was 67 ± 6% and plasma BNP level was 32 ± 30 pg/ml. Plasma BNP levels correlated with age, LV mass index (LVMI), and mitral
E
velocity, respectively (
r
= 0.46,
p
|
| doi_str_mv | 10.1007/s12574-011-0086-9 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_902377359</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1795868834</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-e230f222e99686f5aebbd79354602ae3fed1a6277202a96c64e3522f2b2c92503</originalsourceid><addsrcrecordid>eNp9kE1P3DAQQK2qVdlu-wO4IN_KJcUeJ3Z8RAv9kJC4FAlxsZxkAkaJE2wHaf89XgU4crKteX4aPUKOOfvFGVNnkUOlyoJxXjBWy0J_Ihte16wQZXn7Od9FqQsGAEfkW4yPjFVSg_pKjkCBUlypDbm7wIRhdN76FOnU03mwcbS0CdZ56m0KbgmYXEtnnJPrkA74jEOkebr4FNAm7OjDfsaQ0Ef3jHS2yWG2fSdfejtE_PF6bsnN78v_u7_F1fWff7vzq6ItFU8FgmB93hG1lrXsK4tN0yktqlIysCh67LiVeV_ITy1bWaKoAHpooNVQMbElP1fvHKanBWMyo4stDoP1OC3RaAZCKVHpTJ5-SHKlq1rWtSgzyle0DVOMAXszBzfasDecmUN8s8Y3Ob45xDcH_cmrfmlG7N5_vNXOAKxAzCN_j8E8TkvwOc4H1hc3_JAL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1795868834</pqid></control><display><type>article</type><title>Determinants of plasma brain natriuretic peptide levels in untreated hypertensive patients</title><source>Springer Nature</source><creator>Goda, Akiko ; Nakao, Shinji ; Tsujino, Takeshi ; Yuba, Masao ; Otsuka, Misato ; Matsumoto, Mika ; Yoshida, Chikako ; Naito, Yoshiro ; Lee-Kawabata, Masaaki ; Ohyanagi, Mitsumasa ; Masuyama, Tohru</creator><creatorcontrib>Goda, Akiko ; Nakao, Shinji ; Tsujino, Takeshi ; Yuba, Masao ; Otsuka, Misato ; Matsumoto, Mika ; Yoshida, Chikako ; Naito, Yoshiro ; Lee-Kawabata, Masaaki ; Ohyanagi, Mitsumasa ; Masuyama, Tohru</creatorcontrib><description>Background
Plasma brain natriuretic peptide (BNP) level is elevated in patients with left ventricular (LV) hypertrophy reflecting not only altered LV geometry but LV systolic and/or diastolic dysfunction. However, the values and limitations of BNP measurements are unclear in patients with untreated hypertension. In this study, plasma BNP level was compared with LV geometric and functional characteristics in patients with untreated hypertension.
Methods
Plasma BNP level was measured in 115 patients with untreated hypertension (72 males, 43 females, aged 60 ± 12 years). Routine echo parameters of LV geometry and LV systolic and diastolic performance were also determined.
Results
LV ejection fraction was 67 ± 6% and plasma BNP level was 32 ± 30 pg/ml. Plasma BNP levels correlated with age, LV mass index (LVMI), and mitral
E
velocity, respectively (
r
= 0.46,
p
< 0.05;
r
= 0.21,
p
< 0.05;
r
= 0.29,
p
< 0.05, respectively), but not with systolic blood pressure or relative wall thickness (
r
= 0.01;
r
= −0.02). Plasma BNP level correlated with
E
/
E′
ratio (
r
= 0.27,
p
< 0.05,
n
= 77). When a stepwise multivariate analysis was performed,
E
velocity was selected in addition to age and LVMI as significant correlates of plasma BNP level.
Conclusions
LVMI and
E
velocity were independent determinants of plasma BNP level in patients with untreated hypertension. Plasma BNP level is substantially useful for the screening of abnormalities of LV geometry and/or function in patients with untreated hypertension. Additional echocardiography is useful to assess the mechanism of the elevation of plasma BNP level in untreated hypertensive patients.</description><identifier>ISSN: 1349-0222</identifier><identifier>EISSN: 1880-344X</identifier><identifier>DOI: 10.1007/s12574-011-0086-9</identifier><identifier>PMID: 27277177</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Brain natriuretic peptide ; Cardiology ; Echocardiography ; Heart ; Hypertension ; Hypertrophy ; Imaging ; Medicine ; Medicine & Public Health ; Original Investigation ; Radiology ; Ultrasound ; Ventricle</subject><ispartof>Journal of echocardiography, 2011-09, Vol.9 (3), p.103-108</ispartof><rights>Japanese Society of Echocardiography 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-e230f222e99686f5aebbd79354602ae3fed1a6277202a96c64e3522f2b2c92503</citedby><cites>FETCH-LOGICAL-c471t-e230f222e99686f5aebbd79354602ae3fed1a6277202a96c64e3522f2b2c92503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27277177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goda, Akiko</creatorcontrib><creatorcontrib>Nakao, Shinji</creatorcontrib><creatorcontrib>Tsujino, Takeshi</creatorcontrib><creatorcontrib>Yuba, Masao</creatorcontrib><creatorcontrib>Otsuka, Misato</creatorcontrib><creatorcontrib>Matsumoto, Mika</creatorcontrib><creatorcontrib>Yoshida, Chikako</creatorcontrib><creatorcontrib>Naito, Yoshiro</creatorcontrib><creatorcontrib>Lee-Kawabata, Masaaki</creatorcontrib><creatorcontrib>Ohyanagi, Mitsumasa</creatorcontrib><creatorcontrib>Masuyama, Tohru</creatorcontrib><title>Determinants of plasma brain natriuretic peptide levels in untreated hypertensive patients</title><title>Journal of echocardiography</title><addtitle>J Echocardiogr</addtitle><addtitle>J Echocardiogr</addtitle><description>Background
Plasma brain natriuretic peptide (BNP) level is elevated in patients with left ventricular (LV) hypertrophy reflecting not only altered LV geometry but LV systolic and/or diastolic dysfunction. However, the values and limitations of BNP measurements are unclear in patients with untreated hypertension. In this study, plasma BNP level was compared with LV geometric and functional characteristics in patients with untreated hypertension.
Methods
Plasma BNP level was measured in 115 patients with untreated hypertension (72 males, 43 females, aged 60 ± 12 years). Routine echo parameters of LV geometry and LV systolic and diastolic performance were also determined.
Results
LV ejection fraction was 67 ± 6% and plasma BNP level was 32 ± 30 pg/ml. Plasma BNP levels correlated with age, LV mass index (LVMI), and mitral
E
velocity, respectively (
r
= 0.46,
p
< 0.05;
r
= 0.21,
p
< 0.05;
r
= 0.29,
p
< 0.05, respectively), but not with systolic blood pressure or relative wall thickness (
r
= 0.01;
r
= −0.02). Plasma BNP level correlated with
E
/
E′
ratio (
r
= 0.27,
p
< 0.05,
n
= 77). When a stepwise multivariate analysis was performed,
E
velocity was selected in addition to age and LVMI as significant correlates of plasma BNP level.
Conclusions
LVMI and
E
velocity were independent determinants of plasma BNP level in patients with untreated hypertension. Plasma BNP level is substantially useful for the screening of abnormalities of LV geometry and/or function in patients with untreated hypertension. Additional echocardiography is useful to assess the mechanism of the elevation of plasma BNP level in untreated hypertensive patients.</description><subject>Brain natriuretic peptide</subject><subject>Cardiology</subject><subject>Echocardiography</subject><subject>Heart</subject><subject>Hypertension</subject><subject>Hypertrophy</subject><subject>Imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Investigation</subject><subject>Radiology</subject><subject>Ultrasound</subject><subject>Ventricle</subject><issn>1349-0222</issn><issn>1880-344X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kE1P3DAQQK2qVdlu-wO4IN_KJcUeJ3Z8RAv9kJC4FAlxsZxkAkaJE2wHaf89XgU4crKteX4aPUKOOfvFGVNnkUOlyoJxXjBWy0J_Ihte16wQZXn7Od9FqQsGAEfkW4yPjFVSg_pKjkCBUlypDbm7wIRhdN76FOnU03mwcbS0CdZ56m0KbgmYXEtnnJPrkA74jEOkebr4FNAm7OjDfsaQ0Ef3jHS2yWG2fSdfejtE_PF6bsnN78v_u7_F1fWff7vzq6ItFU8FgmB93hG1lrXsK4tN0yktqlIysCh67LiVeV_ITy1bWaKoAHpooNVQMbElP1fvHKanBWMyo4stDoP1OC3RaAZCKVHpTJ5-SHKlq1rWtSgzyle0DVOMAXszBzfasDecmUN8s8Y3Ob45xDcH_cmrfmlG7N5_vNXOAKxAzCN_j8E8TkvwOc4H1hc3_JAL</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Goda, Akiko</creator><creator>Nakao, Shinji</creator><creator>Tsujino, Takeshi</creator><creator>Yuba, Masao</creator><creator>Otsuka, Misato</creator><creator>Matsumoto, Mika</creator><creator>Yoshida, Chikako</creator><creator>Naito, Yoshiro</creator><creator>Lee-Kawabata, Masaaki</creator><creator>Ohyanagi, Mitsumasa</creator><creator>Masuyama, Tohru</creator><general>Springer Japan</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20110901</creationdate><title>Determinants of plasma brain natriuretic peptide levels in untreated hypertensive patients</title><author>Goda, Akiko ; Nakao, Shinji ; Tsujino, Takeshi ; Yuba, Masao ; Otsuka, Misato ; Matsumoto, Mika ; Yoshida, Chikako ; Naito, Yoshiro ; Lee-Kawabata, Masaaki ; Ohyanagi, Mitsumasa ; Masuyama, Tohru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-e230f222e99686f5aebbd79354602ae3fed1a6277202a96c64e3522f2b2c92503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Brain natriuretic peptide</topic><topic>Cardiology</topic><topic>Echocardiography</topic><topic>Heart</topic><topic>Hypertension</topic><topic>Hypertrophy</topic><topic>Imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Investigation</topic><topic>Radiology</topic><topic>Ultrasound</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goda, Akiko</creatorcontrib><creatorcontrib>Nakao, Shinji</creatorcontrib><creatorcontrib>Tsujino, Takeshi</creatorcontrib><creatorcontrib>Yuba, Masao</creatorcontrib><creatorcontrib>Otsuka, Misato</creatorcontrib><creatorcontrib>Matsumoto, Mika</creatorcontrib><creatorcontrib>Yoshida, Chikako</creatorcontrib><creatorcontrib>Naito, Yoshiro</creatorcontrib><creatorcontrib>Lee-Kawabata, Masaaki</creatorcontrib><creatorcontrib>Ohyanagi, Mitsumasa</creatorcontrib><creatorcontrib>Masuyama, Tohru</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of echocardiography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goda, Akiko</au><au>Nakao, Shinji</au><au>Tsujino, Takeshi</au><au>Yuba, Masao</au><au>Otsuka, Misato</au><au>Matsumoto, Mika</au><au>Yoshida, Chikako</au><au>Naito, Yoshiro</au><au>Lee-Kawabata, Masaaki</au><au>Ohyanagi, Mitsumasa</au><au>Masuyama, Tohru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determinants of plasma brain natriuretic peptide levels in untreated hypertensive patients</atitle><jtitle>Journal of echocardiography</jtitle><stitle>J Echocardiogr</stitle><addtitle>J Echocardiogr</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>9</volume><issue>3</issue><spage>103</spage><epage>108</epage><pages>103-108</pages><issn>1349-0222</issn><eissn>1880-344X</eissn><abstract>Background
Plasma brain natriuretic peptide (BNP) level is elevated in patients with left ventricular (LV) hypertrophy reflecting not only altered LV geometry but LV systolic and/or diastolic dysfunction. However, the values and limitations of BNP measurements are unclear in patients with untreated hypertension. In this study, plasma BNP level was compared with LV geometric and functional characteristics in patients with untreated hypertension.
Methods
Plasma BNP level was measured in 115 patients with untreated hypertension (72 males, 43 females, aged 60 ± 12 years). Routine echo parameters of LV geometry and LV systolic and diastolic performance were also determined.
Results
LV ejection fraction was 67 ± 6% and plasma BNP level was 32 ± 30 pg/ml. Plasma BNP levels correlated with age, LV mass index (LVMI), and mitral
E
velocity, respectively (
r
= 0.46,
p
< 0.05;
r
= 0.21,
p
< 0.05;
r
= 0.29,
p
< 0.05, respectively), but not with systolic blood pressure or relative wall thickness (
r
= 0.01;
r
= −0.02). Plasma BNP level correlated with
E
/
E′
ratio (
r
= 0.27,
p
< 0.05,
n
= 77). When a stepwise multivariate analysis was performed,
E
velocity was selected in addition to age and LVMI as significant correlates of plasma BNP level.
Conclusions
LVMI and
E
velocity were independent determinants of plasma BNP level in patients with untreated hypertension. Plasma BNP level is substantially useful for the screening of abnormalities of LV geometry and/or function in patients with untreated hypertension. Additional echocardiography is useful to assess the mechanism of the elevation of plasma BNP level in untreated hypertensive patients.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>27277177</pmid><doi>10.1007/s12574-011-0086-9</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1349-0222 |
| ispartof | Journal of echocardiography, 2011-09, Vol.9 (3), p.103-108 |
| issn | 1349-0222 1880-344X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_902377359 |
| source | Springer Nature |
| subjects | Brain natriuretic peptide Cardiology Echocardiography Heart Hypertension Hypertrophy Imaging Medicine Medicine & Public Health Original Investigation Radiology Ultrasound Ventricle |
| title | Determinants of plasma brain natriuretic peptide levels in untreated hypertensive patients |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T22%3A36%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Determinants%20of%20plasma%20brain%20natriuretic%20peptide%20levels%20in%20untreated%20hypertensive%20patients&rft.jtitle=Journal%20of%20echocardiography&rft.au=Goda,%20Akiko&rft.date=2011-09-01&rft.volume=9&rft.issue=3&rft.spage=103&rft.epage=108&rft.pages=103-108&rft.issn=1349-0222&rft.eissn=1880-344X&rft_id=info:doi/10.1007/s12574-011-0086-9&rft_dat=%3Cproquest_cross%3E1795868834%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c471t-e230f222e99686f5aebbd79354602ae3fed1a6277202a96c64e3522f2b2c92503%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1795868834&rft_id=info:pmid/27277177&rfr_iscdi=true |