Establishment and characterization of human bladder cancer cell lines BexBra1, BexBra2, and BexBra4

Bladder cancer (BC) is the fourth most common cancer in the USA. In Brazil, BC represents 3% of the total existing carcinomas in the population and represents the second highest incidence among urological tumors. The majority of bladder cancer cell lines available were derived from Caucasians and es...

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Bibliographic Details
Published in:In vitro cellular & developmental biology. Animal 2010-02, Vol.46 (2), p.131-139
Main Authors: Piantino, Camila B, Sousa-Canavez, Juliana M, Srougi, Victor, Salvadori, Fernanda, Kato, Raphael, Ayres, Pedro Paulo R, Srougi, Miguel, Camara-Lopes, Luiz Heraldo, Gattás, Gilka Jorge Figaro, Fridman, Cintia, de Toledo, Fernanda, Santana, Isaque, Leite, Kátia Ramos Moreira
Format: Article
Language:English
Subjects:
Animal Genetics and Genomics
Animals
Biomedical and Life Sciences
Bladder cancer
Cancer
Carcinoma
CELL AND TISSUE MODELS
Cell Biology
Cell Culture
Cell Culture Techniques
Cell Line, Tumor
Cell lines
Chromosomes
Cryopreservation
Development
Developmental Biology
Endothelial cells
epigenetics
Genes, p53
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Karyotyping
KB cells
Life Sciences
Mice
Neoplasia
Polymerase Chain Reaction
Stem Cells
Tumor cell line
Tumor cell lines
Tumors
Urinary bladder
Urinary Bladder Neoplasms - pathology
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Summary:Bladder cancer (BC) is the fourth most common cancer in the USA. In Brazil, BC represents 3% of the total existing carcinomas in the population and represents the second highest incidence among urological tumors. The majority of bladder cancer cell lines available were derived from Caucasians and established in the seventies or eighties. Thus, neoplasia development in these cells likely occurred in environment conditions vastly different than today. In the present study, we report the establishment and characterization of three Brazilian bladder cancer cell lines (BexBra1, BexBra2, and BexBra4). These cell lines may be helpful for dissecting the genetic and epigenetic aspects that trigger the progression of BC. Moreover, the development of a Brazilian representative of the disease will allow us to investigate the potential inter-racial differences of malignancy-associated phenotypes in bladder cancer.
ISSN:1071-2690
1543-706X
DOI:10.1007/s11626-009-9252-z