Myocardial perfusion scintigraphy and echocardiography for detecting coronary artery disease in hypertensive patients: a meta-analysis

Purpose This meta-analysis summarized the accuracy of stress myocardial perfusion scintigraphy (MPS) and stress echocardiography for the diagnosis of coronary artery disease (CAD) in patients with arterial hypertension. Methods We searched for studies in which stress MPS or stress echocardiography w...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2011-11, Vol.38 (11), p.2040-2049
Main Authors: Gargiulo, Paola, Petretta, Mario, Bruzzese, Dario, Cuocolo, Alberto, Prastaro, Maria, D’Amore, Carmen, Vassallo, Enrico, Savarese, Gianluigi, Marciano, Caterina, Paolillo, Stefania, Filardi, Pasquale Perrone
Format: Article
Language:English
Subjects:
Angiography
Cardiology
Cardiovascular disease
Coronary Artery Disease - complications
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - physiopathology
Echocardiography
Echocardiography - methods
EKG
Heart diseases
Humans
Hypertension
Hypertension - complications
Imaging
Medicine
Medicine & Public Health
Meta-analysis
Myocardial Perfusion Imaging - methods
Nuclear Medicine
Oncology
Original Article
Orthopedics
Perfusion
Radiology
Reviews
ROC Curve
Scintigraphy
Stress
Stress, Physiological
Ultrasonic imaging
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Summary:Purpose This meta-analysis summarized the accuracy of stress myocardial perfusion scintigraphy (MPS) and stress echocardiography for the diagnosis of coronary artery disease (CAD) in patients with arterial hypertension. Methods We searched for studies in which stress MPS or stress echocardiography were performed to detect CAD in hypertensive patients, with coronary angiography used as the reference test, published from January 1980 to December 2010. Studies performed in patients with known CAD, acute coronary syndrome and previous revascularization procedures were excluded. Results Of 1,263 studies, 13 met the inclusion criteria. Pooled summary estimates showed that stress MPS had a sensitivity of 0.90 [95% confidence interval (CI) 0.82–0.95] and a specificity of 0.63 (95% CI 0.53–0.72). For stress MPS, the area under the curve (AUC) at the summary receiver-operating characteristic (SROC) graph was 0.83 (95% CI 0.80–0.86). At meta-regression analysis, the presence of positive stress electrocardiography as inclusion criterion was the only significant effect modifier ( p  
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-011-1891-0