Contemporary activity of colistin and polymyxin B against a worldwide collection of Gram-negative pathogens: results from the SENTRY Antimicrobial Surveillance Program (2006-09)

Objectives To comparatively evaluate the antimicrobial activities of colistin and polymyxin B with those of other antimicrobials against a worldwide collection of 40 625 Gram-negative bacilli. Methods Antimicrobial susceptibility testing was performed and interpreted using the CLSI broth microdiluti...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2011-09, Vol.66 (9), p.2070-2074
Main Authors: Gales, Ana C., Jones, Ronald N., Sader, Hélio S.
Format: Article
Language:English
Subjects:
Acinetobacter
Anti-Bacterial Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Brazil - epidemiology
Colistin - pharmacology
Drug Resistance, Bacterial
Enterobacteriaceae
Europe - epidemiology
Geography
Gram-Negative Bacteria - drug effects
Gram-Negative Bacterial Infections - drug therapy
Gram-Negative Bacterial Infections - microbiology
Humans
Klebsiella
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Polymyxin B - pharmacology
Population Surveillance
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Summary:Objectives To comparatively evaluate the antimicrobial activities of colistin and polymyxin B with those of other antimicrobials against a worldwide collection of 40 625 Gram-negative bacilli. Methods Antimicrobial susceptibility testing was performed and interpreted using the CLSI broth microdilution method except for colistin against Enterobacteriaceae. Results The polymyxins showed potent in vitro activities (MIC90, ≤0.5-1 mg/L) against this large collection of clinical isolates, with very low resistance rates (
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkr239