Reversal of imbalance between kynurenic acid and 3-hydroxykynurenine by antipsychotics in medication-naïve and medication-free schizophrenic patients

Highlight ► This manuscript is the first that describes the relationship between metabolites, kynurenic acid and 3-hydroxykynurenine, from kynurenine pathway in schizophrenia.

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2011-11, Vol.25 (8), p.1576-1581
Main Authors: Myint, A.M, Schwarz, M.J, Verkerk, R, Mueller, H.H, Zach, J, Scharpé, S, Steinbusch, H.W.M, Leonard, B.E, Kim, Y.K
Format: Article
Language:English
Subjects:
3-Hydroxykynurenine
Adult
Algorithms
Allergy and Immunology
Antipsychotic Agents - adverse effects
Antipsychotic Agents - therapeutic use
Antipsychotics
Chromatography, High Pressure Liquid
Diagnostic and Statistical Manual of Mental Disorders
Female
Humans
Kynurenic acid
Kynurenic Acid - metabolism
Kynurenine
Kynurenine - analogs & derivatives
Kynurenine - metabolism
Male
Middle Aged
Patient Discharge
Psychiatry
Schizophrenia
Schizophrenia - drug therapy
Schizophrenia - metabolism
Schizophrenic Psychology
Spectrophotometry, Ultraviolet
Treatment Outcome
Tryptophan - metabolism
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Summary:Highlight ► This manuscript is the first that describes the relationship between metabolites, kynurenic acid and 3-hydroxykynurenine, from kynurenine pathway in schizophrenia.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2011.05.005