Galectin-8 is expressed by villous and extravillous trophoblast of the human placenta

Abstract Galectins (gals) as multifunctional animal lectins are of great potential significance for establishment and function of the placenta, due to their capacity to modulate cellular functions including proliferation, adhesion, and invasion. Human trophoblast is known to express gal-1, gal-3 and...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2011-11, Vol.32 (11), p.909-911
Main Authors: KOLUNDZIC, N, BOJIC-TRBOJEVIC, Z, RADOJCIC, Lj, PETRONIJEVIC, M, VICOVAC, Lj
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cells, Cultured
Chorionic Villi - metabolism
Embryology: invertebrates and vertebrates. Teratology
Female
Fundamental and applied biological sciences. Psychology
Galectin-8
Galectins
Galectins - metabolism
HTR-8/SVneo
Humans
Immunohistochemistry
Internal Medicine
Obstetrics and Gynecology
Placenta - metabolism
Placental bed
Pregnancy
Pregnancy Trimester, First - metabolism
Trophoblast
Trophoblasts - metabolism
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Summary:Abstract Galectins (gals) as multifunctional animal lectins are of great potential significance for establishment and function of the placenta, due to their capacity to modulate cellular functions including proliferation, adhesion, and invasion. Human trophoblast is known to express gal-1, gal-3 and gal-13 proteins, as well as mRNAs for gal-14, -16 and -17. This study was undertaken to establish cellular distribution of gal-8, not previously associated with trophoblast, since we have recently detected gal-8 RNA and protein in cytotrophoblast cell material. Results of immunolocalization showed that gal-8 was expressed by villous and extravillous cytotrophoblast.
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2011.07.087