Association between Arg399Gln polymorphism of X-ray repair cross-complementing 1 (XRCC1) gene and sporadic endometrial cancer in the Polish population

Endometrial cancer is one of the most common malignant neoplasms which appear in the uterine body. X-ray repair cross-complementing 1 (XRCC1) protein can be involved in the repair of DNA lesions, which are known to contribute to endometrial cancer. The genotype analysis of XRCC1 Arg399Gln gene polym...

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Bibliographic Details
Published in:European journal of gynaecological oncology 2011, Vol.32 (5), p.491-495
Main Authors: Samulak, D, Romanowicz-Makowska, H, Smolarz, B, Kulig, A, Sporny, S
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alleles
DNA Repair
DNA-Binding Proteins - genetics
Endometrial Neoplasms - epidemiology
Endometrial Neoplasms - genetics
Female
Genotype
Humans
Middle Aged
Poland - epidemiology
Polymorphism, Genetic
X-ray Repair Cross Complementing Protein 1
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Summary:Endometrial cancer is one of the most common malignant neoplasms which appear in the uterine body. X-ray repair cross-complementing 1 (XRCC1) protein can be involved in the repair of DNA lesions, which are known to contribute to endometrial cancer. The genotype analysis of XRCC1 Arg399Gln gene polymorphisms for 456 endometrial cancer patients and 300 controls of cancer-free subjects in the Polish population were performed using the PCR-based restriction fragment length polymorphism (PCR-RFLP). The association between endometrial cancer occurrence and the Gln/Gln genotype of the Arg399Gln polymorphism (odds ratio, OR 2.28; 95% confidence interval, CI 2.02-2.54) was found. The Gln/Gln genotype of XRCC1 increased the risk of type I endometrial cancer occurrence (OR = 2.42, 95% CI = 2.12-2.72). No statistically significant association was found between gene polymorphisms and endometrial cancer risk factors such as BMI, HRT, uterine bleeding, endometrial ultrasound transvaginal, diabetes and hypertension. The results support the hypothesis that the Arg399Gln polymorphism of the XRCC1 gene may be associated with the incidence of sporadic endometrial cancer in Polish women.
ISSN:0392-2936