Daily urine iodine excretion while consuming a low-iodine diet in preparation for radioactive iodine therapy in a high iodine intake area

Summary Objective  Recommended durations of low‐iodine diet (LID) in preparation for radioactive iodine therapy (RAIT) vary among major guidelines and are important for patients in areas where iodine intake is high. The aim of this study was to investigate daily changes in urine iodine excretion aft...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2011-12, Vol.75 (6), p.851-856
Main Authors: Kim, Hee Kyung, Lee, Soo Youn, In Lee, Ji, Jang, Hye Won, Kim, Soo Kyoung, Chung, Hye Soo, Tan, Alice Hyun Kyung, Hur, Kyu Yeon, Kim, Jae Hyeon, Chung, Jae Hoon, Kim, Sun Wook
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Carcinoma - metabolism
Carcinoma - radiotherapy
Carcinoma - urine
Creatinine - urine
Diet
Eating - physiology
Endocrinopathies
Female
Fundamental and applied biological sciences. Psychology
Geography
Humans
Iodine - deficiency
Iodine - metabolism
Iodine - supply & distribution
Iodine - urine
Iodine Radioisotopes - therapeutic use
Male
Medical sciences
Middle Aged
Radioactive materials
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - radiotherapy
Thyroid Neoplasms - urine
Urine
Vertebrates: endocrinology
Young Adult
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Summary:Summary Objective  Recommended durations of low‐iodine diet (LID) in preparation for radioactive iodine therapy (RAIT) vary among major guidelines and are important for patients in areas where iodine intake is high. The aim of this study was to investigate daily changes in urine iodine excretion after starting a LID. Design  The daily iodine/creatinine (I/Cr) ratios and simple iodine concentration (simple I) of morning spot urine from 19 patients with differentiated thyroid carcinoma were measured for 2 weeks from the start of LID for RAIT preparation. We set the cut‐off of I/Cr and simple I for poor LID preparation at >66·2 μg/gCr and >150 μg/l, respectively. The day when daily I/Cr or simple I became equal to or below the cut‐off both by 95% CI and 90th percentile was defined as the end‐point for the appropriate duration of LID for RAIT. Results  On day 6 of LID, the I/Cr ratio decreased below the cut‐off (≤66·2 μg/gCr) both by 95% CI (0–60·8) and by 90th percentile (51·9). Simple I reached the cut‐off (≤150 μg/l) on day 3 by both parameters (95%CI: 2·3–90·5; 90th percentile: 126·5). The morning spot‐urine I/Cr and simple I on day 7 and day 14 were significantly lower than on day 0 (P 
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2011.04157.x