Adipokines and Their Role in Allergies

Both allergic disorders and obesity keep increasing in industrialized countries. Even though a strong association between obesity and allergy-related diseases has been reported in several studies, no published data show a scientific and firm link in-between the two conditions. In general, obesity an...

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Bibliographic Details
Published in:International journal of immunopathology and pharmacology 2011-10, Vol.24 (4_suppl), p.13-16
Main Authors: Ciprandi, G, Caimmi, D, Raschetti, R, Del Giudice, M Miraglia, Salpietro, C, Caimmi, S, Castellazzi, AM
Format: Article
Language:English
Subjects:
Adipokines - physiology
Adiponectin - physiology
Asthma - physiopathology
Child
Humans
Hypersensitivity - physiopathology
Leptin - physiology
Rhinitis, Allergic, Seasonal - physiopathology
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Summary:Both allergic disorders and obesity keep increasing in industrialized countries. Even though a strong association between obesity and allergy-related diseases has been reported in several studies, no published data show a scientific and firm link in-between the two conditions. In general, obesity and weight gain have been associated with an increased risk of asthma and allergic rhinitis. Asthma, allergic rhinitis and obesity have a common inflammatory pattern that could therefore justify their association. In fact, the chronic inflammation that characterizes the increase in white adipose tissue typically pushes the immune system toward a Th2 pattern. Such a polarization might, consequentially, worsen a pre-existing allergic disease or even stimulate the evolution from a sensitization to a respiratory form of allergy. Several studies have been published on the role of different adipokines on allergic diseases. We focus our review on the role of adipokines on asthma and allergic rhinitis.
ISSN:0394-6320
2058-7384
DOI:10.1177/03946320110240S403