17β-estradiol levels and oxidative balance in a population of pre-, peri-, and post-menopausal women

Background. The high incidence of various diseases observed in post-menopausal women has been widely associated to the decline of 17β-estradiol (E2) occurring in correspondence of menopausal transition. One of the mechanisms suggested to explain this link takes into account the ability of E2 to coun...

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Published in:Gynecological endocrinology 2011-12, Vol.27 (12), p.1028-1032
Main Authors: Cervellati, Carlo, Pansini, Francesco Saverio, Bonaccorsi, Gloria, Bergamini, Carlo Maria, Patella, Alfredo, Casali, Ferruccio, Fantini, Gian Franco, Pascale, Giuliana, Castaldini, Cristina, Ferrazzini, Stefania, Ridolfi, Francesca, Cervellati, Giulia, Cremonini, Eleonora, Christodoulou, Panagiota, Bagni, Bruno
Format: Article
Language:English
Subjects:
Adult
Aged
amenhorrea
Antioxidants - metabolism
Body Weights and Measures
Cross-Sectional Studies
Estradiol - analysis
Estradiol - blood
estrogens
Female
Homeostasis - physiology
Humans
Hydrogen Peroxide - blood
Menopause
Middle Aged
Oxidants - blood
Oxidants - metabolism
Oxidation-Reduction
Oxidative Stress - drug effects
Oxidative Stress - physiology
Perimenopause - blood
Perimenopause - metabolism
Postmenopause - blood
Postmenopause - metabolism
Premenopause - blood
Premenopause - metabolism
Young Adult
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Summary:Background. The high incidence of various diseases observed in post-menopausal women has been widely associated to the decline of 17β-estradiol (E2) occurring in correspondence of menopausal transition. One of the mechanisms suggested to explain this link takes into account the ability of E2 to counteract oxidative stress (OS) which is believed to play an important role in several pathogenic processes. Aim. To investigate whether stages of women's life characterized by different levels of E2 influence OS. Subjects and methods. We conducted a cross sectional study of OS markers in 159 women subdivided in 65 pre-menopausal, 36 peri-menopausal, and 58 post-menopausal classified according to the Staging of Reproductive Aging Workshop (STRAW) criteria. E2, follicle-stimulating hormone, and markers of OS including hydroperoxides, thiols, uric acid, total and residual antioxidant power, were assessed. Results. After adjustment for covariates, only total antioxidant power was significantly different according to menopausal status (p
ISSN:0951-3590
1473-0766
DOI:10.3109/09513590.2011.579653