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17β-estradiol levels and oxidative balance in a population of pre-, peri-, and post-menopausal women
Background. The high incidence of various diseases observed in post-menopausal women has been widely associated to the decline of 17β-estradiol (E2) occurring in correspondence of menopausal transition. One of the mechanisms suggested to explain this link takes into account the ability of E2 to coun...
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| Published in: | Gynecological endocrinology 2011-12, Vol.27 (12), p.1028-1032 |
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| creator | Cervellati, Carlo Pansini, Francesco Saverio Bonaccorsi, Gloria Bergamini, Carlo Maria Patella, Alfredo Casali, Ferruccio Fantini, Gian Franco Pascale, Giuliana Castaldini, Cristina Ferrazzini, Stefania Ridolfi, Francesca Cervellati, Giulia Cremonini, Eleonora Christodoulou, Panagiota Bagni, Bruno |
| description | Background. The high incidence of various diseases observed in post-menopausal women has been widely associated to the decline of 17β-estradiol (E2) occurring in correspondence of menopausal transition. One of the mechanisms suggested to explain this link takes into account the ability of E2 to counteract oxidative stress (OS) which is believed to play an important role in several pathogenic processes.
Aim. To investigate whether stages of women's life characterized by different levels of E2 influence OS.
Subjects and methods. We conducted a cross sectional study of OS markers in 159 women subdivided in 65 pre-menopausal, 36 peri-menopausal, and 58 post-menopausal classified according to the Staging of Reproductive Aging Workshop (STRAW) criteria. E2, follicle-stimulating hormone, and markers of OS including hydroperoxides, thiols, uric acid, total and residual antioxidant power, were assessed.
Results. After adjustment for covariates, only total antioxidant power was significantly different according to menopausal status (p |
| doi_str_mv | 10.3109/09513590.2011.579653 |
| format | article |
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Aim. To investigate whether stages of women's life characterized by different levels of E2 influence OS.
Subjects and methods. We conducted a cross sectional study of OS markers in 159 women subdivided in 65 pre-menopausal, 36 peri-menopausal, and 58 post-menopausal classified according to the Staging of Reproductive Aging Workshop (STRAW) criteria. E2, follicle-stimulating hormone, and markers of OS including hydroperoxides, thiols, uric acid, total and residual antioxidant power, were assessed.
Results. After adjustment for covariates, only total antioxidant power was significantly different according to menopausal status (p <0.01), with lower value in pre- with respect peri- and post-menopausal women. No significant correlations between E2 levels and OS markers were detected.
Conclusions. Endogen E2, and, consequently, its decline during menopausal transition, is not a determinant factor for OS.</description><identifier>ISSN: 0951-3590</identifier><identifier>EISSN: 1473-0766</identifier><identifier>DOI: 10.3109/09513590.2011.579653</identifier><identifier>PMID: 21615234</identifier><language>eng</language><publisher>England: Informa Healthcare</publisher><subject>Adult ; Aged ; amenhorrea ; Antioxidants - metabolism ; Body Weights and Measures ; Cross-Sectional Studies ; Estradiol - analysis ; Estradiol - blood ; estrogens ; Female ; Homeostasis - physiology ; Humans ; Hydrogen Peroxide - blood ; Menopause ; Middle Aged ; Oxidants - blood ; Oxidants - metabolism ; Oxidation-Reduction ; Oxidative Stress - drug effects ; Oxidative Stress - physiology ; Perimenopause - blood ; Perimenopause - metabolism ; Postmenopause - blood ; Postmenopause - metabolism ; Premenopause - blood ; Premenopause - metabolism ; Young Adult</subject><ispartof>Gynecological endocrinology, 2011-12, Vol.27 (12), p.1028-1032</ispartof><rights>2011 Informa UK, Ltd. 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-7e1ee34194a78a08cb21027a6f6d0f2e6524e3ba757a40cec26c052fafbccb063</citedby><cites>FETCH-LOGICAL-c332t-7e1ee34194a78a08cb21027a6f6d0f2e6524e3ba757a40cec26c052fafbccb063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21615234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cervellati, Carlo</creatorcontrib><creatorcontrib>Pansini, Francesco Saverio</creatorcontrib><creatorcontrib>Bonaccorsi, Gloria</creatorcontrib><creatorcontrib>Bergamini, Carlo Maria</creatorcontrib><creatorcontrib>Patella, Alfredo</creatorcontrib><creatorcontrib>Casali, Ferruccio</creatorcontrib><creatorcontrib>Fantini, Gian Franco</creatorcontrib><creatorcontrib>Pascale, Giuliana</creatorcontrib><creatorcontrib>Castaldini, Cristina</creatorcontrib><creatorcontrib>Ferrazzini, Stefania</creatorcontrib><creatorcontrib>Ridolfi, Francesca</creatorcontrib><creatorcontrib>Cervellati, Giulia</creatorcontrib><creatorcontrib>Cremonini, Eleonora</creatorcontrib><creatorcontrib>Christodoulou, Panagiota</creatorcontrib><creatorcontrib>Bagni, Bruno</creatorcontrib><title>17β-estradiol levels and oxidative balance in a population of pre-, peri-, and post-menopausal women</title><title>Gynecological endocrinology</title><addtitle>Gynecol Endocrinol</addtitle><description>Background. The high incidence of various diseases observed in post-menopausal women has been widely associated to the decline of 17β-estradiol (E2) occurring in correspondence of menopausal transition. One of the mechanisms suggested to explain this link takes into account the ability of E2 to counteract oxidative stress (OS) which is believed to play an important role in several pathogenic processes.
Aim. To investigate whether stages of women's life characterized by different levels of E2 influence OS.
Subjects and methods. We conducted a cross sectional study of OS markers in 159 women subdivided in 65 pre-menopausal, 36 peri-menopausal, and 58 post-menopausal classified according to the Staging of Reproductive Aging Workshop (STRAW) criteria. E2, follicle-stimulating hormone, and markers of OS including hydroperoxides, thiols, uric acid, total and residual antioxidant power, were assessed.
Results. After adjustment for covariates, only total antioxidant power was significantly different according to menopausal status (p <0.01), with lower value in pre- with respect peri- and post-menopausal women. No significant correlations between E2 levels and OS markers were detected.
Conclusions. Endogen E2, and, consequently, its decline during menopausal transition, is not a determinant factor for OS.</description><subject>Adult</subject><subject>Aged</subject><subject>amenhorrea</subject><subject>Antioxidants - metabolism</subject><subject>Body Weights and Measures</subject><subject>Cross-Sectional Studies</subject><subject>Estradiol - analysis</subject><subject>Estradiol - blood</subject><subject>estrogens</subject><subject>Female</subject><subject>Homeostasis - physiology</subject><subject>Humans</subject><subject>Hydrogen Peroxide - blood</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>Oxidants - blood</subject><subject>Oxidants - metabolism</subject><subject>Oxidation-Reduction</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidative Stress - physiology</subject><subject>Perimenopause - blood</subject><subject>Perimenopause - metabolism</subject><subject>Postmenopause - blood</subject><subject>Postmenopause - metabolism</subject><subject>Premenopause - blood</subject><subject>Premenopause - metabolism</subject><subject>Young Adult</subject><issn>0951-3590</issn><issn>1473-0766</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kMtu1TAQhi0EoofCGyDkHRty8C12swGhClqkSmxgbU2cserKiYOd9PJaPAjPhMNpkdh0NbL1_XP5CHnN2V5y1r1nXctl27G9YJzvW9PpVj4hO66MbJjR-inZbUizMUfkRSlXjHGpjHhOjgTXvBVS7Qhy8_tXg2XJMIQUacRrjIXCNNB0GwZYwjXSHiJMDmmYKNA5zWus_2miydM5Y_OOzphDLVtqTmVpRpzSDGuBSG9SfbwkzzzEgq_u6zH58eXz99Pz5uLb2dfTTxeNk1IsjUGOKBXvFJgTYCeuF5wJA9rrgXmBuhUKZQ-mNaCYQye0Y63w4HvneqblMXl76Dvn9HOtV9kxFIexro9pLbZjkivN_pLqQLqcSsno7ZzDCPnOcmY3v_bBr9382oPfGntzP2DtRxz-hR6EVuDjAQiTT3mEm5TjYBe4iyn7XC2GsrV_dMSH_zpcIsTl0kFGe5XWPFV_j-_4B8uQneg</recordid><startdate>201112</startdate><enddate>201112</enddate><creator>Cervellati, Carlo</creator><creator>Pansini, Francesco Saverio</creator><creator>Bonaccorsi, Gloria</creator><creator>Bergamini, Carlo Maria</creator><creator>Patella, Alfredo</creator><creator>Casali, Ferruccio</creator><creator>Fantini, Gian Franco</creator><creator>Pascale, Giuliana</creator><creator>Castaldini, Cristina</creator><creator>Ferrazzini, Stefania</creator><creator>Ridolfi, Francesca</creator><creator>Cervellati, Giulia</creator><creator>Cremonini, Eleonora</creator><creator>Christodoulou, Panagiota</creator><creator>Bagni, Bruno</creator><general>Informa Healthcare</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201112</creationdate><title>17β-estradiol levels and oxidative balance in a population of pre-, peri-, and post-menopausal women</title><author>Cervellati, Carlo ; Pansini, Francesco Saverio ; Bonaccorsi, Gloria ; Bergamini, Carlo Maria ; Patella, Alfredo ; Casali, Ferruccio ; Fantini, Gian Franco ; Pascale, Giuliana ; Castaldini, Cristina ; Ferrazzini, Stefania ; Ridolfi, Francesca ; Cervellati, Giulia ; Cremonini, Eleonora ; Christodoulou, Panagiota ; Bagni, Bruno</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-7e1ee34194a78a08cb21027a6f6d0f2e6524e3ba757a40cec26c052fafbccb063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>amenhorrea</topic><topic>Antioxidants - metabolism</topic><topic>Body Weights and Measures</topic><topic>Cross-Sectional Studies</topic><topic>Estradiol - analysis</topic><topic>Estradiol - blood</topic><topic>estrogens</topic><topic>Female</topic><topic>Homeostasis - physiology</topic><topic>Humans</topic><topic>Hydrogen Peroxide - blood</topic><topic>Menopause</topic><topic>Middle Aged</topic><topic>Oxidants - blood</topic><topic>Oxidants - metabolism</topic><topic>Oxidation-Reduction</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidative Stress - physiology</topic><topic>Perimenopause - blood</topic><topic>Perimenopause - metabolism</topic><topic>Postmenopause - blood</topic><topic>Postmenopause - metabolism</topic><topic>Premenopause - blood</topic><topic>Premenopause - metabolism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cervellati, Carlo</creatorcontrib><creatorcontrib>Pansini, Francesco Saverio</creatorcontrib><creatorcontrib>Bonaccorsi, Gloria</creatorcontrib><creatorcontrib>Bergamini, Carlo Maria</creatorcontrib><creatorcontrib>Patella, Alfredo</creatorcontrib><creatorcontrib>Casali, Ferruccio</creatorcontrib><creatorcontrib>Fantini, Gian Franco</creatorcontrib><creatorcontrib>Pascale, Giuliana</creatorcontrib><creatorcontrib>Castaldini, Cristina</creatorcontrib><creatorcontrib>Ferrazzini, Stefania</creatorcontrib><creatorcontrib>Ridolfi, Francesca</creatorcontrib><creatorcontrib>Cervellati, Giulia</creatorcontrib><creatorcontrib>Cremonini, Eleonora</creatorcontrib><creatorcontrib>Christodoulou, Panagiota</creatorcontrib><creatorcontrib>Bagni, Bruno</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecological endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cervellati, Carlo</au><au>Pansini, Francesco Saverio</au><au>Bonaccorsi, Gloria</au><au>Bergamini, Carlo Maria</au><au>Patella, Alfredo</au><au>Casali, Ferruccio</au><au>Fantini, Gian Franco</au><au>Pascale, Giuliana</au><au>Castaldini, Cristina</au><au>Ferrazzini, Stefania</au><au>Ridolfi, Francesca</au><au>Cervellati, Giulia</au><au>Cremonini, Eleonora</au><au>Christodoulou, Panagiota</au><au>Bagni, Bruno</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>17β-estradiol levels and oxidative balance in a population of pre-, peri-, and post-menopausal women</atitle><jtitle>Gynecological endocrinology</jtitle><addtitle>Gynecol Endocrinol</addtitle><date>2011-12</date><risdate>2011</risdate><volume>27</volume><issue>12</issue><spage>1028</spage><epage>1032</epage><pages>1028-1032</pages><issn>0951-3590</issn><eissn>1473-0766</eissn><abstract>Background. The high incidence of various diseases observed in post-menopausal women has been widely associated to the decline of 17β-estradiol (E2) occurring in correspondence of menopausal transition. One of the mechanisms suggested to explain this link takes into account the ability of E2 to counteract oxidative stress (OS) which is believed to play an important role in several pathogenic processes.
Aim. To investigate whether stages of women's life characterized by different levels of E2 influence OS.
Subjects and methods. We conducted a cross sectional study of OS markers in 159 women subdivided in 65 pre-menopausal, 36 peri-menopausal, and 58 post-menopausal classified according to the Staging of Reproductive Aging Workshop (STRAW) criteria. E2, follicle-stimulating hormone, and markers of OS including hydroperoxides, thiols, uric acid, total and residual antioxidant power, were assessed.
Results. After adjustment for covariates, only total antioxidant power was significantly different according to menopausal status (p <0.01), with lower value in pre- with respect peri- and post-menopausal women. No significant correlations between E2 levels and OS markers were detected.
Conclusions. Endogen E2, and, consequently, its decline during menopausal transition, is not a determinant factor for OS.</abstract><cop>England</cop><pub>Informa Healthcare</pub><pmid>21615234</pmid><doi>10.3109/09513590.2011.579653</doi><tpages>5</tpages></addata></record> |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Adult Aged amenhorrea Antioxidants - metabolism Body Weights and Measures Cross-Sectional Studies Estradiol - analysis Estradiol - blood estrogens Female Homeostasis - physiology Humans Hydrogen Peroxide - blood Menopause Middle Aged Oxidants - blood Oxidants - metabolism Oxidation-Reduction Oxidative Stress - drug effects Oxidative Stress - physiology Perimenopause - blood Perimenopause - metabolism Postmenopause - blood Postmenopause - metabolism Premenopause - blood Premenopause - metabolism Young Adult |
| title | 17β-estradiol levels and oxidative balance in a population of pre-, peri-, and post-menopausal women |
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