Ionic-Surfactant-Coated Burkholderia cepacia Lipase as a Highly Active and Enantioselective Catalyst for the Dynamic Kinetic Resolution of Secondary Alcohols

With a coat for activity: A highly active enzyme was prepared by coating Burkholderia cepacia lipase with an ionic surfactant for use in dynamic kinetic resolution (DKR). Important features of this enzyme include: the fastest DKR of 1‐phenylethanol, the highly enantioselective DKR of a wide range of...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2011-11, Vol.50 (46), p.10944-10948
Main Authors: Kim, Hyunjin, Choi, Yoon Kyung, Lee, Jusuk, Lee, Eungyeong, Park, Jaiwook, Kim, Mahn-Joo
Format: Article
Language:English
Subjects:
alcohols
Alcohols - metabolism
Binding Sites
Biocatalysis
Burkholderia cepacia - enzymology
catalysts
Catalytic Domain
dynamic kinetic resolution
Ions - chemistry
Kinetics
Lipase - chemistry
Lipase - metabolism
lipases
ruthenium
Stereoisomerism
Surface-Active Agents - chemistry
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Summary:With a coat for activity: A highly active enzyme was prepared by coating Burkholderia cepacia lipase with an ionic surfactant for use in dynamic kinetic resolution (DKR). Important features of this enzyme include: the fastest DKR of 1‐phenylethanol, the highly enantioselective DKR of a wide range of secondary alcohols (RCH(OH)Ar), and the switching of lipase enantioselectivity in DKR depending on the shape of the aliphatic chain (R).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201104141