Diffraction enhanced imaging and x-ray fluorescence microtomography for analyzing biological samples

In this work, breast tissue samples were investigated in order to verify the distribution of certain elements by x‐ray fluorescence computed tomography (XRFCT) correlated with the characteristics and pathology of each tissue observed by diffraction enhanced imaging (DEI). The DEI system can show det...

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Bibliographic Details
Published in:X-ray spectrometry 2007-07, Vol.36 (4), p.247-253
Main Authors: Rocha, H. S., Pereira, G. R., Anjos, M. J., Faria, P., Kellermann, G., Pérez, C. A., Tirao, G., Mazzaro, I., Giles, C., Lopes, R. T.
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemistry
Exact sciences and technology
Spectrometric and optical methods
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Summary:In this work, breast tissue samples were investigated in order to verify the distribution of certain elements by x‐ray fluorescence computed tomography (XRFCT) correlated with the characteristics and pathology of each tissue observed by diffraction enhanced imaging (DEI). The DEI system can show details in low attenuation tissues. It is based on the contrast imaging obtained by extinction, diffraction and refraction characteristics and can improve reduction in false positive and false negative diagnoses. XRFCT allows mapping of all elements within the sample, since even a minute fluorescence signal can be detected. DEI imaging techniques revealed the complex structure of the disease, confirmed by the histological section, and showed microstructures in all planes of the sample. The XRFCT showed the distribution of Zn, Cu and Fe at higher concentration. Copyright © 2007 John Wiley & Sons, Ltd.
ISSN:0049-8246
1097-4539
DOI:10.1002/xrs.973