Preparation and properties of macroporous brushite bone cements

In the present work a macroporous brushite bone cement for use either as an injected or mouldable paste, or in the shape of preformed grafts, has been investigated. Macropores have been introduced by adding to the powder single crystals of mannitol which worked as a porogen. The size of the crystals...

Full description

Saved in:
Bibliographic Details
Published in:Acta biomaterialia 2009-07, Vol.5 (6), p.2161-2168
Main Authors: Cama, G., Barberis, F., Botter, R., Cirillo, P., Capurro, M., Quarto, R., Scaglione, S., Finocchio, E., Mussi, V., Valbusa, U.
Format: Article
Language:English
Subjects:
Adhesiveness
Animals
Bone cement
Bone Cements - chemistry
Brushite
Cell adhesion
Cell Adhesion - physiology
Cell Line
Compressive Strength
Elastic Modulus
Hardness
Mannitol - chemistry
Materials Testing
Mechanical properties
Mice
Osteoblasts - cytology
Osteoblasts - physiology
Porosity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the present work a macroporous brushite bone cement for use either as an injected or mouldable paste, or in the shape of preformed grafts, has been investigated. Macropores have been introduced by adding to the powder single crystals of mannitol which worked as a porogen. The size of the crystals was in the range of 250–500 μm in diameter, suitable for cell infiltration, with a shape ratio between 3 and 6. From compression tests on cylindrical samples an elastic modulus in the range 2.5–4.2 GPa and a compressive strength in the range 17.5–32.6 MPa were obtained for a volume fraction of macropores varying between 15 and 0%. Thus the compressive strength exceeded in all tests the maximum value currently attributed to cancellous bone.
ISSN:1742-7061
1878-7568
DOI:10.1016/j.actbio.2009.02.012