Synthetic gene networks: the next wave in biotechnology?

Engineering novel, reusable gene networks to provide greater control over cellular processes is one of the goals of the emerging discipline of synthetic biology. This article reviews the landmark literature pertaining to the development of synthetic gene networks, the engineering framework used to d...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2009-06, Vol.27 (6), p.368-374
Main Author: Bhalerao, Kaustubh D
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biosensing Techniques
Biosensors
Biotechnology
Biotechnology - trends
Circuits
Control theory
Deoxyribonucleic acid
Design
DNA
Engineers
Fundamental and applied biological sciences. Psychology
Gene expression
Gene Regulatory Networks
Genetic Engineering
Internal Medicine
Mathematical models
Medical research
Synthetic biology
Technological change
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Summary:Engineering novel, reusable gene networks to provide greater control over cellular processes is one of the goals of the emerging discipline of synthetic biology. This article reviews the landmark literature pertaining to the development of synthetic gene networks, the engineering framework used to design and characterize them and the technological developments on the horizon that could potentially advance the field in new directions. As gene network engineering enters its second decade, an attempt is also made to outline the challenges in advancing this nascent field, especially with regard to the practical limitations of component reusability and reliability and the opportunities that present themselves in the development of novel gene expression controllers and single-cell biosensors.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2009.03.003