Specific inflammatory microenvironments in the zones of the fetal membranes at term delivery

Objective The purpose of this study was to examine the histologic and immunologic differences between fetal membrane zones after membrane rupture at term delivery. Study Design Fetal membrane explants from postrupture zones (periplacental, middle, rupture) were obtained from women following spontane...

Full description

Saved in:
Bibliographic Details
Published in:American journal of obstetrics and gynecology 2011-09, Vol.205 (3), p.235.e15-235.e24
Main Authors: Gomez-Lopez, Nardhy, MSc, PhD, Vadillo-Perez, Lourdes, Hernandez-Carbajal, Ana, BSc, Godines-Enriquez, Myrna, MD, MSc, Olson, David M., PhD, FRCOG, Vadillo-Ortega, Felipe, MD, PhD
Format: Article
Language:English
Subjects:
Adult
Cellular Microenvironment - physiology
Delivery, Obstetric
Extraembryonic Membranes - metabolism
Female
fetal membrane zones
Humans
inflammation
Inflammation - metabolism
Interleukin-1 - metabolism
Interleukin-1beta - metabolism
Matrix Metalloproteinase 9 - metabolism
Obstetrics and Gynecology
parturition
Pregnancy
Term Birth
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective The purpose of this study was to examine the histologic and immunologic differences between fetal membrane zones after membrane rupture at term delivery. Study Design Fetal membrane explants from postrupture zones (periplacental, middle, rupture) were obtained from women following spontaneous vaginal delivery at term (n = 5). Tissues for histology, protein extracts, and RNA were isolated. Results The collagen distribution decreased and the leukocyte density increased from the periplacental zone to the rupture zone. T cells were mainly present in the rupture zone and granulocytes in the middle zone. CXCL10, CXCR1, ICAM-1, -2, PSEL, tumor necrosis factor alpha, and matrix metalloproteinase-9 levels were higher in the middle zone than in the rupture zone and periplacental zone ( P < .021). Interleukin-1beta and CXCL8 levels were higher in the rupture zone than in the middle zone and periplacental zone ( P = .018 and P < .0001). Conclusion During labor specific immunologic microenvironments are created in the zones of the fetal membrane that may be involved in their rupture at the end of gestation.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2011.04.019