Cardiac Resynchronization Therapy Reduces Left Atrial Volume and the Risk of Atrial Tachyarrhythmias in MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy)

• Published in: Journal of the American College of Cardiology 2011-10, Vol.58 (16), p.1682-1689
• Main Authors: Brenyo, Andrew, MD, Link, Mark S., MD, Barsheshet, Alon, MD, Moss, Arthur J., MD, Zareba, Wojciech, MD, PhD, Wang, Paul J., MD, McNitt, Scott, MS, Huang, David, MD, Foster, Elyse, MD, Estes, Mark, MD, Solomon, Scott D., MD, Goldenberg, Ilan, MD
• Format: Article
• Language: English
• Subjects: Aged; atrial tachyarrhythmias; Atrium; Biological and medical sciences; Cardiac arrhythmia; cardiac resynchronization therapy; Cardiac Resynchronization Therapy - methods; Cardiology; Cardiology. Vascular system; Cardiovascular; Clinical trials; Defibrillators; Defibrillators, Implantable; Drug therapy; Echocardiography - methods; Female; Fibrillation; Heart; Heart Atria - pathology; Heart attacks; Heart diseases; heart failure; Heart Failure - therapy; Humans; Internal Medicine; Male; Medical sciences; Middle Aged; Mortality; Multivariate Analysis; Proportional Hazards Models; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Risk; tachyarrhythmia; Tachycardia; Tachycardia - therapy
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2011.07.020

Objectives We hypothesized that reductions in left atrial volume (LAV) with a cardiac resynchronization therapy–defibrillator (CRT-D) would translate into a subsequent reduction in the risk of atrial tachyarrhythmias (AT). Background There is limited information regarding the effect of CRT-D on the risk of AT. Methods Percent reduction in LAV at 1 year following CRT-D implantation (pre-specified as low [lowest quartile: