Effects of Simvastatin on Osseointegration in a Canine Total Hip Arthroplasty Model: An Experimental Study

Abstract Simvastatin was recently demonstrated to stimulate bone morphogenetic protein–2 expression, leading to bone formation. The present study was designed to evaluate whether simvastatin administered by injection could promote osseointegration in a canine total hip arthroplasty model. Fifteen do...

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Bibliographic Details
Published in:The Journal of arthroplasty 2011-12, Vol.26 (8), p.1534-1539
Main Authors: Yin, Han, PhD, Li, Jianmin, MD, Yu, Xiuchun, PhD, Fu, Zhihou, PhD
Format: Article
Language:English
Subjects:
animal study
Animals
Arthroplasty, Replacement, Hip - methods
Dogs
Dose-Response Relationship, Drug
Female
Hip Joint - drug effects
Hip Joint - pathology
Hip Joint - ultrastructure
Hip Prosthesis
implant interface
Injections, Subcutaneous
Male
Microscopy, Electron, Scanning
Models, Animal
Orthopedics
osseointegration
Osseointegration - drug effects
simvastatin
Simvastatin - administration & dosage
Simvastatin - pharmacology
total hip arthroplasty
Treatment Outcome
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Summary:Abstract Simvastatin was recently demonstrated to stimulate bone morphogenetic protein–2 expression, leading to bone formation. The present study was designed to evaluate whether simvastatin administered by injection could promote osseointegration in a canine total hip arthroplasty model. Fifteen dogs were divided into 3 groups of 5 dogs each: group 1 (high-dosage simvastatin, 6.0 mg/[kg d]), group 2 (low-dosage simvastatin, 3.0 mg/[kg d]), and a control group (isotonic saline, 3.0 mg/[kg d]). Osseointegration was assessed by using the push-out test, scanning electron microscopy, energy-dispersive spectrometer microanalysis, and histomorphometric examination. The results showed higher mechanical strength, greater area of bone covering the femoral component, and higher bone-implant contact in group 1 than in the other 2 groups. Our findings indicate that simvastatin administered by injection could contribute significantly to osseointegration in a canine total hip arthroplasty model.
ISSN:0883-5403
1532-8406
DOI:10.1016/j.arth.2010.10.008