Intraoperative Detection of Thyroid Carcinoma by Fourier Transform Infrared Spectrometry

Background Fourier transform infrared (FTIR) spectroscopy is a powerful tool for distinguishing cancerous tissue from normal one. Our aim in this study was to establish tissue discriminant analysis for thyroid malignancy and benign samples intraoperatively using FTIR spectroscopy. Methods Seventeen...

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Bibliographic Details
Published in:The Journal of surgical research 2011-12, Vol.171 (2), p.650-656
Main Authors: Zhang, Xiaoqing, Ph.D., M.D, Xu, Yizhuang, Ph.D, Zhang, Yuanfu, B.D, Wang, Lixin, M.D, Hou, Chunsheng, M.D, Zhou, Xiaosi, M.D, Ling, Xiaofeng, M.D, Xu, Zhi, M.D
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
canonical discriminant analysis
Carcinoma, Papillary - diagnosis
Carcinoma, Papillary - surgery
Diagnosis, Differential
Discriminant Analysis
Endocrinopathies
FTIR
General aspects
Goiter, Nodular - diagnosis
Goiter, Nodular - surgery
Humans
Intraoperative Period
Malignant tumors
Medical sciences
Middle Aged
Neoplasms - diagnosis
Neoplasms - surgery
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Reproducibility of Results
Sensitivity and Specificity
Spectroscopy, Fourier Transform Infrared - methods
Spectroscopy, Fourier Transform Infrared - standards
Surgery
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - surgery
thyroid tumor
Thyroid. Thyroid axis (diseases)
Young Adult
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Summary:Background Fourier transform infrared (FTIR) spectroscopy is a powerful tool for distinguishing cancerous tissue from normal one. Our aim in this study was to establish tissue discriminant analysis for thyroid malignancy and benign samples intraoperatively using FTIR spectroscopy. Methods Seventeen papillary thyroid cancer and 43 nodular goiter tissues were obtained and underwent FTIR spectroscopy scanning intraoperatively. Nine peak positions were identified and assigned. Peak position values and wave intensity ratios were measured in every single spectrum. Data of malignant and benign groups were compared and equations of canonical discriminant analysis were established. Results Peak positions of P1640, P1240, P1550, and peak intensity ratios of I3375/I1460, I1640/I1460, I1400/I1460, I1550/I1080, I1080/I1460, and I1640/I1550 of thyroid papillary carcinoma group are significantly different from nodular goiter group. The sensitivity, specificity, and accuracy rate of the discriminants are 83.3%, 95.2%, and 91.67%, respectively. Conclusion FTIR spectroscopy technique in combination with canonical discriminant analysis method can achieve fast and accurate discrimination for malignant and benign thyroid nodules during operation
ISSN:0022-4804
1095-8673
DOI:10.1016/j.jss.2010.05.031