Cyanoacrylate Adhesive for the Closure of Truncal Veins: 60-Day Swine Model Results

• Published in: Vascular and endovascular surgery 2011-10, Vol.45 (7), p.631-635
• Main Authors: Almeida, Jose I., Min, Robert J., Raabe, Rod, McLean, D. J., Madsen, Monte
• Format: Article
• Language: English
• Subjects: Abdominal Muscles - blood supply; Animals; Biological and medical sciences; Blood. Blood coagulation. Reticuloendothelial system; Catheterization, Peripheral; Cyanoacrylates - administration & dosage; Feasibility Studies; Fibrosis; Foreign-Body Reaction - chemically induced; Foreign-Body Reaction - pathology; Injections, Intravenous; Medical sciences; Models, Animal; Pharmacology. Drug treatments; Sclerosing Solutions - administration & dosage; Sclerotherapy - methods; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Swine; Time Factors; Ultrasonography, Interventional; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels; Veins - drug effects; Veins - pathology
• ISSN: 1538-5744; 1938-9116
• DOI: 10.1177/1538574411413938

Background: The introduction of cyanoacrylate (CA) within a blood vessel triggers polymerization, followed by an inflammatory reaction. Methods: A sheath was positioned 2.0 cm caudad to the junction of the superficial epigastric and abdominus rectus veins in 2 swine, followed by ultrasound-guided injection of 0.16 mL of CA glue. After glue delivery, the catheter was pulled back 3 cm, compression was applied to the treatment site, and the process was repeated for the entire length. At 60 days postimplantation, the veins were harvested surgically and examined histologically. Results: The histologic changes were consistent with a chronic foreign-body-type inflammatory response. Venous closure, segmental wall thickening, and fibrosis were observed. Conclusion: Injection of CA is feasible for closure of superficial veins in animal models. Vein closure is achieved via an inflammatory process which ultimately leads to fibrosis.