Breast conservative surgery after neoadjuvant chemotherapy in breast cancer patients: Comparison of two tumor localization methods

Abstract Aims The key to surgical planning for breast conservative treatment (BCT) after neoadjuvant chemotherapy (NAC) is tumor localization. Tumor marking can be performed using either skin tattoo or metallic marker. The objective of this study is to compare both types of tumor localization marker...

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Bibliographic Details
Published in:European journal of surgical oncology 2011-12, Vol.37 (12), p.1038-1043
Main Authors: Espinosa-Bravo, M, Sao Avilés, A, Esgueva, A, Córdoba, O, Rodriguez, J, Cortadellas, T, Mendoza, C, Salvador, R, Xercavins, J, Rubio, I.T
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Carcinoma, Ductal, Breast - diagnosis
Carcinoma, Ductal, Breast - surgery
Carcinoma, Lobular - diagnosis
Carcinoma, Lobular - surgery
Conservative surgery
Female
Hematology, Oncology and Palliative Medicine
Humans
Mastectomy, Segmental - instrumentation
Mastectomy, Segmental - methods
Metallic marker
Middle Aged
Neoadjuvant Therapy - methods
Neoadjuvant treatment
Neoplasm Staging
Surgery
Tattooing
Treatment Outcome
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Summary:Abstract Aims The key to surgical planning for breast conservative treatment (BCT) after neoadjuvant chemotherapy (NAC) is tumor localization. Tumor marking can be performed using either skin tattoo or metallic marker. The objective of this study is to compare both types of tumor localization markers and to assess which techniques improve BCT in achieving a complete resection without compromise margins. Methods 149 patients between 1999 and 2009 were eligible for the study. The skin tattoo group (TG) included 118 patients and the metallic marker group (MG) included 31 patients. Both markers were placed before starting NAC. Results Median clinical tumor volume was 10.3 cm3 in the TG and 22.4 cm3 in the MG ( p  = 0.051). After NAC treatment, there were no significant statistically differences in both groups regarding complete clinical response, partial clinical response, and complete and partial pathological response. Median pathological tumor volume was: 0.8 cm3 in the TG and 0.69 cm3 in the MG ( p  = 0.8). Lumpectomy volume was bigger in the TG (268 cm3 ) than MG (143 cm3 ); p  
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2011.08.136