Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation

This review presents observations on the role of Epac proteins (exchange protein directly activated by cAMP) in immunoregulation mechanisms. Signaling pathways that involve Epac proteins and their domain organization and functions are considered. The role of Epac1 protein expressed in the immune sys...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2011-09, Vol.76 (9), p.981-998
Main Author: Shirshev, S. V.
Format: Article
Language:English
Subjects:
Analysis
Animals
Antigens
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Cellular biology
Chemotaxis, Leukocyte
Cyclic AMP - immunology
Guanine Nucleotide Exchange Factors - genetics
Guanine Nucleotide Exchange Factors - immunology
Humans
Immune system
Immunity
Immunology
Life Sciences
Lymphocytes
Microbiology
Phagocytosis
Proteins
Review
T cell receptors
T cells
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Summary:This review presents observations on the role of Epac proteins (exchange protein directly activated by cAMP) in immunoregulation mechanisms. Signaling pathways that involve Epac proteins and their domain organization and functions are considered. The role of Epac1 protein expressed in the immune system cells is especially emphasized. Molecular mechanisms of the cAMP-dependent signal via Epac1 are analyzed in monocytes/macrophages, T-cells, and B-lymphocytes. The role of Epac1 is shown in the regulation of adhesion, leukocyte chemotaxis, as well as in phagocytosis and bacterial killing. The molecular cascade initiated by Epac1 is examined under conditions of antigen activation of T-cells and immature B-lymphocytes.
ISSN:0006-2979
1608-3040
DOI:10.1134/S000629791109001X