Coenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: A randomized double-blind, placebo controlled trial

Background: Several lines of evidence show the implication of oxidative stress in the etiology of male infertility. Recently, the role of coenzyme Q 10 (CoQ 10 ) in the prevention and treatment of disease has been intensively probed. However, definitive efficacy studies in oligoasthenoteratozoosperm...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2011-09, Vol.34 (8), p.e224-e228
Main Authors: Nadjarzadeh, A., Sadeghi, M. R., Amirjannati, N., Vafa, M. R., Motevalian, S. A., Gohari, M. R., Akhondi, M. A., Yavari, P., Shidfar, F.
Format: Article
Language:English
Subjects:
Adult
Asthenozoospermia - physiopathology
Dietary Supplements
Double-Blind Method
Endocrinology
Female
Humans
Lipid Peroxidation
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Original Articles
Oxidation-Reduction
Oxidative Stress - drug effects
Placebos
Semen - cytology
Semen - drug effects
Spermatozoa - abnormalities
Spermatozoa - drug effects
Spermatozoa - metabolism
Ubiquinone - administration & dosage
Ubiquinone - analogs & derivatives
Ubiquinone - pharmacology
Vitamins - pharmacology
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Summary:Background: Several lines of evidence show the implication of oxidative stress in the etiology of male infertility. Recently, the role of coenzyme Q 10 (CoQ 10 ) in the prevention and treatment of disease has been intensively probed. However, definitive efficacy studies in oligoasthenoteratozoospermia (OAT) have not been completed yet. Aim: To evaluate the effect of CoQ 10 supplementation on semen parameters in idiopathic OAT (iOAT). Material/subjects and methods: A double-blind placebo controlled clinical trial was carried out. A total of 47 infertile men with iOAT were randomly assigned to receive 200 mg CoQ 10 daily or placebo during a 12-week period. Semen parameters were determined using microscopic evaluation according to World Health Organization guidelines. Lipid peroxidation was assessed by measuring the concentration of plasma malondialdehyde. We evaluated the total antioxidant capacity of seminal plasma. To compare variables between and within the 2 groups we used independent t-test and Paired t-test. Results: The trial showed non-significant changes in semen parameters of CoQ 10 group. However, concentrations of thiobarbituric acid-reactive substances were significantly ( p
ISSN:0391-4097
1720-8386
DOI:10.3275/7572