LTR retrotransposons in the Aspergillus fumigatus and A. nidulans genomes

Fungi of the genus Aspergillus can infect all tissues and organs, causing invasive mycosis (aspergillosis). This disease can be fatal, especially in immunocompromised patients. Microbiological monitoring of these infectious agents is obligatory in modern medical facilities. Mobile elements can be us...

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Bibliographic Details
Published in:Molecular biology (New York) 2007-10, Vol.41 (5), p.756-763
Main Authors: Novikova, O S, Fet, V, Blinov, A G
Format: Article
Language:English
Subjects:
Aspergillosis
Aspergillus fumigatus
Aspergillus nidulans
Bacteria
Fungi
Genomes
genomics
Immunocompromised hosts
Mutation
Mycosis
Phylogeny
Retrotransposons
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Summary:Fungi of the genus Aspergillus can infect all tissues and organs, causing invasive mycosis (aspergillosis). This disease can be fatal, especially in immunocompromised patients. Microbiological monitoring of these infectious agents is obligatory in modern medical facilities. Mobile elements can be used as markers to identify the Aspergillus species and strains found indoors as well as to diagnose aspergillosis. Genomic sequences of two Aspergillus species, A. fumigatus and A. nidulans, were analyzed in silico in order to detect LTR retrotransposons. These species were found to considerably differ in the composition of retrotransposon families. One of the families, present in both Aspergillus species, was phylogenetically quite different from all known fungal retrotransposons. The majority of its elements were damaged copies. Nevertheless, allegedly undamaged LTR retrotransposon copies were described that contained intact ORFs and might be active.
ISSN:0026-8933
1608-3245
DOI:10.1134/S0026893307050081