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Food contaminant acrylamide increases expression of Cox-2 and nitric oxide synthase in breast epithelial cells
Acrylamide has been discovered in foods cooked at high temperature. A potentially harmful effect of this dietary component has been suggested by data indicating its association with increased breast cancer. This study investigated the potential effects of acrylamide in nontumorigenic breast cells by...
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| Published in: | Toxicology and industrial health 2011-02, Vol.27 (1), p.11-18 |
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| cites | cdi_FETCH-LOGICAL-c395t-5f0e26fed3fa54d076e77a665179fb85c717748fac8af491744b8ab42cd968c43 |
| container_end_page | 18 |
| container_issue | 1 |
| container_start_page | 11 |
| container_title | Toxicology and industrial health |
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| creator | Lyn-Cook, Lascelles E Tareke, Eden Word, Beverly Starlard-Davenport, Athena Lyn-Cook, Beverly D Hammons, George J |
| description | Acrylamide has been discovered in foods cooked at high temperature. A potentially harmful effect of this dietary component has been suggested by data indicating its association with increased breast cancer. This study investigated the potential effects of acrylamide in nontumorigenic breast cells by assessing expression levels of inducible nitric oxide synthase (iNOS) and cycloogenase-2 (Cox-2) and NOS activity, which are known to be early molecular changes in disease formation. Treatment of cells with acrylamide increased levels of iNOS (both expression and activity) and Cox-2. Its potent metabolite, glycidamide, also induced both iNOS and Cox-2, with induction of iNOS occurring at a lower concentration. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), another food-borne carcinogen, was found to induce Cox-2 expression. Combining acrylamide with PhIP did not result in a further increase. These studies suggest that further research is needed to determine the role of carcinogens formed from cooking foods in inducing early molecular changes associated with breast cancer. |
| doi_str_mv | 10.1177/0748233710380217 |
| format | article |
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A potentially harmful effect of this dietary component has been suggested by data indicating its association with increased breast cancer. This study investigated the potential effects of acrylamide in nontumorigenic breast cells by assessing expression levels of inducible nitric oxide synthase (iNOS) and cycloogenase-2 (Cox-2) and NOS activity, which are known to be early molecular changes in disease formation. Treatment of cells with acrylamide increased levels of iNOS (both expression and activity) and Cox-2. Its potent metabolite, glycidamide, also induced both iNOS and Cox-2, with induction of iNOS occurring at a lower concentration. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), another food-borne carcinogen, was found to induce Cox-2 expression. Combining acrylamide with PhIP did not result in a further increase. These studies suggest that further research is needed to determine the role of carcinogens formed from cooking foods in inducing early molecular changes associated with breast cancer.</description><identifier>ISSN: 0748-2337</identifier><identifier>EISSN: 1477-0393</identifier><identifier>DOI: 10.1177/0748233710380217</identifier><identifier>PMID: 20713430</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Acrylamide - toxicity ; Breast cancer ; Carcinogens ; Carcinogens - toxicity ; Cell Line ; Cooking ; Cooking - methods ; Cyclooxygenase 2 - metabolism ; Epithelial Cells ; Epoxy Compounds - toxicity ; Female ; Food ; Food Contamination ; High temperature ; Humans ; Imidazoles - toxicity ; Investigations ; Nitric oxide ; Nitric Oxide Synthase Type II - metabolism ; Toxicology</subject><ispartof>Toxicology and industrial health, 2011-02, Vol.27 (1), p.11-18</ispartof><rights>The Author(s) 2011</rights><rights>SAGE Publications © Feb 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-5f0e26fed3fa54d076e77a665179fb85c717748fac8af491744b8ab42cd968c43</citedby><cites>FETCH-LOGICAL-c395t-5f0e26fed3fa54d076e77a665179fb85c717748fac8af491744b8ab42cd968c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923,79134</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20713430$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lyn-Cook, Lascelles E</creatorcontrib><creatorcontrib>Tareke, Eden</creatorcontrib><creatorcontrib>Word, Beverly</creatorcontrib><creatorcontrib>Starlard-Davenport, Athena</creatorcontrib><creatorcontrib>Lyn-Cook, Beverly D</creatorcontrib><creatorcontrib>Hammons, George J</creatorcontrib><title>Food contaminant acrylamide increases expression of Cox-2 and nitric oxide synthase in breast epithelial cells</title><title>Toxicology and industrial health</title><addtitle>Toxicol Ind Health</addtitle><description>Acrylamide has been discovered in foods cooked at high temperature. A potentially harmful effect of this dietary component has been suggested by data indicating its association with increased breast cancer. This study investigated the potential effects of acrylamide in nontumorigenic breast cells by assessing expression levels of inducible nitric oxide synthase (iNOS) and cycloogenase-2 (Cox-2) and NOS activity, which are known to be early molecular changes in disease formation. Treatment of cells with acrylamide increased levels of iNOS (both expression and activity) and Cox-2. Its potent metabolite, glycidamide, also induced both iNOS and Cox-2, with induction of iNOS occurring at a lower concentration. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), another food-borne carcinogen, was found to induce Cox-2 expression. Combining acrylamide with PhIP did not result in a further increase. These studies suggest that further research is needed to determine the role of carcinogens formed from cooking foods in inducing early molecular changes associated with breast cancer.</description><subject>Acrylamide - toxicity</subject><subject>Breast cancer</subject><subject>Carcinogens</subject><subject>Carcinogens - toxicity</subject><subject>Cell Line</subject><subject>Cooking</subject><subject>Cooking - methods</subject><subject>Cyclooxygenase 2 - metabolism</subject><subject>Epithelial Cells</subject><subject>Epoxy Compounds - toxicity</subject><subject>Female</subject><subject>Food</subject><subject>Food Contamination</subject><subject>High temperature</subject><subject>Humans</subject><subject>Imidazoles - toxicity</subject><subject>Investigations</subject><subject>Nitric oxide</subject><subject>Nitric Oxide Synthase Type II - 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A potentially harmful effect of this dietary component has been suggested by data indicating its association with increased breast cancer. This study investigated the potential effects of acrylamide in nontumorigenic breast cells by assessing expression levels of inducible nitric oxide synthase (iNOS) and cycloogenase-2 (Cox-2) and NOS activity, which are known to be early molecular changes in disease formation. Treatment of cells with acrylamide increased levels of iNOS (both expression and activity) and Cox-2. Its potent metabolite, glycidamide, also induced both iNOS and Cox-2, with induction of iNOS occurring at a lower concentration. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), another food-borne carcinogen, was found to induce Cox-2 expression. Combining acrylamide with PhIP did not result in a further increase. 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| ispartof | Toxicology and industrial health, 2011-02, Vol.27 (1), p.11-18 |
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| subjects | Acrylamide - toxicity Breast cancer Carcinogens Carcinogens - toxicity Cell Line Cooking Cooking - methods Cyclooxygenase 2 - metabolism Epithelial Cells Epoxy Compounds - toxicity Female Food Food Contamination High temperature Humans Imidazoles - toxicity Investigations Nitric oxide Nitric Oxide Synthase Type II - metabolism Toxicology |
| title | Food contaminant acrylamide increases expression of Cox-2 and nitric oxide synthase in breast epithelial cells |
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