A new method to estimate rCBF using IMP and SPECT without any blood sampling

We developed and evaluated a method to measure rCBF without any blood sampling by using iodine- 123 IMP and SPECT. An integral of arterial input function, the integral taken from the value 0 to T of the variable Ca(t)dt, can be expressed as TC(T)/CO, where TC(T) is radioactivity delivered to the bod...

Full description

Saved in:
Bibliographic Details
Published in:Annals of nuclear medicine 2000-12, Vol.14 (6), p.433-440
Main Authors: Nishizawa, S, Shiozaki, T, Ueno, M, Toyoda, H, Shimono, T, Kamoto, Y, Fujita, T, Yonekura, Y, Konishi, J
Format: Article
Language:English
Subjects:
Adult
Aged
Blood
Brain - blood supply
Carbon monoxide
Cardiac Output
Cerebrovascular Circulation - physiology
Cerebrovascular Disorders - diagnostic imaging
Cerebrovascular Disorders - physiopathology
Chest
Evaluation
Female
Humans
Iodine
Iodine isotopes
Iofetamine - pharmacokinetics
Male
Microspheres
Middle Aged
Pulmonary Circulation
Radioactivity
Radiopharmaceuticals - pharmacokinetics
Regional Blood Flow
Regression Analysis
Sampling
Single photon emission computed tomography
Tomography, Emission-Computed, Single-Photon - methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We developed and evaluated a method to measure rCBF without any blood sampling by using iodine- 123 IMP and SPECT. An integral of arterial input function, the integral taken from the value 0 to T of the variable Ca(t)dt, can be expressed as TC(T)/CO, where TC(T) is radioactivity delivered to the body in T minutes and CO is cardiac output. If T is acceptably small, rCBF can be determined by means of a microsphere model analysis with IMP as Cb(T)/(TC(T)/CO), where Cb(T) is cerebral radioactivity at T minutes. We derived TC(T) and CO from a chest dynamic scan. The method was applied to 45 patients who underwent rCBF studies (58 studies) with arterial blood sampling (ABS). Data from the chest scan were analyzed in comparison with ABS data in the first 28 studies, and equations for correction yielding an accurate TC(T)/CO were derived. The validity of the proposed method was evaluated in the subsequent 30 studies. The method yielded rCBF (rCBF-test) which agreed well with rCBF obtained by a two-compartment model analysis of dynamic SPECT and ABS data (rCBF-ref) with the mean and SD of differences between rCBF-test and rCBF-ref being 1.0 and 2.7 ml/100 g/min, respectively. In eleven subjects who underwent more than two studies, a percentage change in rCBF-test between the studies also closely approximated that of rCBF-ref (y = 1.11 x + 2.63, r = 0.92). The method can be used with acceptable reliability to measure rCBF without any blood sampling.
ISSN:0914-7187
1864-6433
DOI:10.1007/bf02988289