Adenovirus Infections in Hospitalized Patients in Israel: Epidemiology and Molecular Characterization

Adenoviruses can cause a broad spectrum of clinical diseases, most of which are self-limited. However, adenovirus infection can occasionally result in severe or lethal infection. Fifty-five adenovirus serotypes are known today, and they are classified into 7 subgroups (subgroups A to G). Here we exa...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2011-02, Vol.49 (2), p.597-601
Main Authors: Mandelboim, Michal, Dror, Pnina, Azar, Roberto, Bromberg, Michal, Mendelson, Ella
Format: Article
Language:English
Subjects:
Adenoviridae - classification
Adenoviridae - genetics
Adenoviridae - isolation & purification
Adenovirus
Adenovirus Infections, Human - epidemiology
Adenovirus Infections, Human - virology
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Child
Child, Preschool
DNA, Viral - chemistry
DNA, Viral - genetics
Female
Fundamental and applied biological sciences. Psychology
Genotype
Hospitals
Humans
Infant
Infant, Newborn
Israel - epidemiology
Male
Microbiology
Middle Aged
Miscellaneous
Molecular Typing
Polymerase Chain Reaction - methods
Prevalence
Sequence Analysis, DNA
Virology
Young Adult
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Summary:Adenoviruses can cause a broad spectrum of clinical diseases, most of which are self-limited. However, adenovirus infection can occasionally result in severe or lethal infection. Fifty-five adenovirus serotypes are known today, and they are classified into 7 subgroups (subgroups A to G). Here we examined 282 samples derived from hospitalized patients in Israel (September 2006 to August 2008) who were diagnosed as suffering from adenovirus infections. We used a recently described PCR amplification method and subsequent sequencing to identify the adenovirus. In addition, we studied the medical charts of 106 hospitalized patients from Sheba Medical Center in Israel. The most prevalent adenovirus serotypes found were serotypes 1 (22.8%), 2 (19.2%), 7 (18%), and 3 (14%). In addition, we identified several serotypes that have not been identified previously in Israel. Overall, serotypes of subgroup B were found to be approximately 4 times more prevalent among immunocompromised children than among generally healthy children (52.6%; P < 0.007). The realization that the virus subtypes are different among healthy and immunocompromised patients may lead to more efficient treatment of adenovirus infections among immunocompromised children in the future.
ISSN:0095-1137
1098-660X
DOI:10.1128/jcm.00979-10