Sustained virological response to interferon-α plus ribavirin decreases inflammation and endothelial dysfunction markers in HIV/HCV co-infected patients

• Published in: Journal of antimicrobial chemotherapy 2011-03, Vol.66 (3), p.645-649
• Main Authors: GUZMAN-FULGENCIO, María, BERENGUER, Juan, RESINO, Salvador, FERNANDEZ DE CASTRO, Isabel, MICHELOUD, Dariela, LOPEZ, Juan Carlos, COSIN, Jaime, MIRALLES, Pilar, LORENTE, Raquel, ALDAMIZ-ECHEVARRIA, Teresa, ANGELES MUNOZ-FERNANDEZ, M
• Format: Article
• Language: English
• Subjects: Adult; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents - administration & dosage; Biological and medical sciences; Biomarkers - blood; E-Selectin - blood; Endothelial Cells - physiology; Female; Hepatitis C - complications; Hepatitis C - drug therapy; Hepatitis C - pathology; Hepatitis C virus; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - pathology; Human immunodeficiency virus; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Intercellular Adhesion Molecule-1 - blood; Interferon-alpha - administration & dosage; Male; Medical sciences; Middle Aged; P-Selectin - blood; Pharmacology. Drug treatments; Receptors, Tumor Necrosis Factor, Type I - blood; Retrospective Studies; Ribavirin - administration & dosage; Treatment Outcome; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral hepatitis; Viral Load
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/dkq518

Hepatitis C virus (HCV) antiviral therapy might lead to decreased chronic immune activation and endothelial dysfunction associated with cardiovascular risk. The aim was to evaluate the effect of HCV eradication on serum markers of inflammation and endothelial dysfunction markers in HIV/HCV co-infected patients. We carried out a retrospective study of 69 HIV/HCV co-infected patients on interferon (IFN)-α plus ribavirin. In addition, 47 HIV-infected subjects were selected as a control group. A sustained virological response (SVR) was defined as an undetectable HCV viral load up to 24 weeks after the end of treatment. Tumour necrosis factor (TNF) receptor-1 (TNF-R1), soluble E-selectin (sE-selectin), soluble P-selectin (sP-selectin), soluble intercellular adhesion molecule 1 (sICAM-1) and soluble vascular cell adhesion molecule 1 (sVCAM-1) were measured using a multiplex immunoassay kit. HIV/HCV co-infected patients had higher values of soluble TNF-R1 (sTNF-R1), sE-selectin and sICAM-1 than HIV mono-infected patients (P