Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma

Higher maternal intake of vitamin D during pregnancy is associated with a lower risk of wheezing in offspring. The relationship between cord-blood levels of 25-hydroxyvitamin D (25[OH]D) and childhood wheezing is unknown. We hypothesized that cord-blood levels would be inversely associated with risk...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2011-01, Vol.127 (1), p.e180-e187
Main Authors: Camargo, Jr, Carlos A, Ingham, Tristram, Wickens, Kristin, Thadhani, Ravi, Silvers, Karen M, Epton, Michael J, Town, G Ian, Pattemore, Philip K, Espinola, Janice A, Crane, Julian
Format: Article
Language:English
Subjects:
Alfacalcidol
Analysis
Asthma
Asthma - blood
Asthma - epidemiology
Asthma in children
Blood
Calcifediol
Childhood asthma
Demographic aspects
Female
Fetal blood
Fetal Blood - chemistry
Health risk assessment
Humans
Infant, Newborn
Male
Maternal & child health
Measurement
Pediatrics
Prospective Studies
Respiratory diseases
Respiratory Sounds
Respiratory tract infections
Respiratory Tract Infections - blood
Respiratory Tract Infections - epidemiology
Risk Factors
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Wheeze
Wheezing
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Summary:Higher maternal intake of vitamin D during pregnancy is associated with a lower risk of wheezing in offspring. The relationship between cord-blood levels of 25-hydroxyvitamin D (25[OH]D) and childhood wheezing is unknown. We hypothesized that cord-blood levels would be inversely associated with risk of respiratory infection, wheezing, and asthma. Cord blood from 922 newborns was tested for 25(OH)D. Parents were asked if their child had a history of respiratory infection at 3 months of age or a history of wheezing at 15 months of age and then annually thereafter. Incident asthma was defined as doctor-diagnosed asthma by the time the child was 5 years old and reported inhaler use or wheezing since the age of 4 years. The median cord-blood level of 25(OH)D was 44 nmol/L (interquartile range: 29-78). Follow-up was 89% at the age of 5 years. Adjusting for the season of birth, 25(OH)D had an inverse association with risk of respiratory infection by 3 months of age (odds ratio: 1.00 [reference] for ≥75 nmol/L, 1.39 for 25-74 nmol/L, and 2.16 [95% confidence interval: 1.35-3.46] for
ISSN:0031-4005
1098-4275
1098-4275
DOI:10.1542/peds.2010-0442