Polymorphism of the Tumor Necrosis Factor [alpha] Gene in Patients with Infiltrative Tuberculosis from the Bashkortostan Populations

The polymorphism at position -308 of the TNF-α gene promoter was analyzed in three ethnic groups and in patients with infiltrative pulmonary tuberculosis from Bashkortostan. No interethnic difference in allele or genotype frequency distribution was observed. The frequency of allele TNF2 in tuberculo...

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Bibliographic Details
Published in:Molecular biology (New York) 2002-09, Vol.36 (5), p.631-633
Main Authors: Bikmaeva, A R, Sibiryak, S V, Valiakhmetova, D Kh, Khusnutdinova, E K
Format: Article
Language:English
Subjects:
Ethnic groups
Frequency distribution
Gene frequency
Gene polymorphism
Immune response
Lung
Mycobacterium
Promoters
Risk factors
Tuberculosis
Tumor necrosis factor- alpha
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Summary:The polymorphism at position -308 of the TNF-α gene promoter was analyzed in three ethnic groups and in patients with infiltrative pulmonary tuberculosis from Bashkortostan. No interethnic difference in allele or genotype frequency distribution was observed. The frequency of allele TNF2 in tuberculosis patients was significantly higher than in controls (χ^sup 2^ = 11.69, p = 0.001), suggesting association of this allele with higher risk of pulmonary tuberculosis or with markedly disturbed immune response.[PUBLICATION ABSTRACT]
ISSN:0026-8933
1608-3245
DOI:10.1023/A:1020659027135