Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative of aspartic acid

( S )-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative, showed remarkable glutathione peroxidase (GPx)-like activity, attesting to its antioxidant potential. However, the stability and toxicity of this compound has not yet been investigated. The present study...

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Bibliographic Details
Published in:Archives of toxicology 2011, Vol.85 (1), p.43-49
Main Authors: Meinerz, Daiane Francine, Sudati, Jéssie H., dos Santos, Danúbia B., Frediani, Andressa, Alberto, Eduardo E., Allebrandt, Josiane, Franco, Jeferson L., Barbosa, Nilda B. V., Aschner, Michael, da Rocha, João Batista T.
Format: Article
Language:English
Subjects:
Administration, Oral
Analysis of Variance
Animals
Antioxidants
Antioxidants - pharmacology
Aspartic Acid - analogs & derivatives
Aspartic Acid - toxicity
Biochemistry
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Brain
Chemical mutagenesis
Comet Assay
DNA Damage
Environmental Health
Ferrous Compounds - metabolism
Glutathione Peroxidase - metabolism
Lethal Dose 50
Male
Medical sciences
Mice
Molecular Toxicology
Occupational Medicine/Industrial Medicine
Organometallic Compounds - metabolism
Organometallic Compounds - pharmacology
Organometallic Compounds - toxicity
Pharmacology/Toxicology
Rats
Rats, Wistar
Rodents
Succinates - pharmacology
Succinates - toxicity
Tellurium - metabolism
Thiobarbituric Acid Reactive Substances - metabolism
Toxicology
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Summary:( S )-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative, showed remarkable glutathione peroxidase (GPx)-like activity, attesting to its antioxidant potential. However, the stability and toxicity of this compound has not yet been investigated. The present study was designed to investigate the pharmacological/toxicological properties of this compound in vitro and in vivo. In vitro, this telluroamino acid derivative significantly blocked spontaneous and Fe(II)-induced TBARS formation in rat brain homogenates, demonstrating high antioxidant activity. In addition, it exhibited GPx-like and thiol oxidase activities. However, when subcutaneously administered to mice, ( S )-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate indicated genotoxic and mutagenic effect in adult male mice. Considering the differential effects of ( S )-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate in vitro and in vivo, additional experiments are needed to elucidate the mechanism(s) by which this compound displays its antioxidant/toxicological effects.
ISSN:0340-5761
1432-0738
DOI:10.1007/s00204-010-0555-3