Induction of a State of Iron Limitation in Uropathogenic Escherichia coli CFT073 by Cranberry-Derived Proanthocyanidins as Revealed by Microarray Analysis

Transcriptional profiles of uropathogenic Escherichia coli CFT073 exposed to cranberry-derived proanthocyanidins (PACs) were determined. Our results indicate that bacteria grown on media supplemented with PACs were iron deprived. To our knowledge, this is the first time that PACs have been shown to...

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Bibliographic Details
Published in:Applied and Environmental Microbiology 2011-02, Vol.77 (4), p.1532-1535
Main Authors: Hidalgo, Gabriela, Ponton, André, Fatisson, Julien, O'May, Che, Asadishad, Bahareh, Schinner, Tim, Tufenkji, Nathalie
Format: Article
Language:English
Subjects:
Bacterial Adhesion - drug effects
Bacteriology
Biological and medical sciences
DNA microarrays
E coli
Escherichia coli
Food Microbiology
Fundamental and applied biological sciences. Psychology
Gene Expression Profiling
Iron
Iron - metabolism
Iron Chelating Agents - pharmacology
Metabolism
Microarray Analysis
Microbiology
Plant Extracts
Proanthocyanidins - pharmacology
Reverse Transcriptase Polymerase Chain Reaction
Uropathogenic Escherichia coli - genetics
Uropathogenic Escherichia coli - growth & development
Uropathogenic Escherichia coli - metabolism
Vaccinium macrocarpon - chemistry
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Summary:Transcriptional profiles of uropathogenic Escherichia coli CFT073 exposed to cranberry-derived proanthocyanidins (PACs) were determined. Our results indicate that bacteria grown on media supplemented with PACs were iron deprived. To our knowledge, this is the first time that PACs have been shown to induce a state of iron limitation in this bacterium.
ISSN:0099-2240
1098-5336
1098-6596
DOI:10.1128/AEM.02201-10