HIV and Age Do Not Substantially Interact in HIV-Associated Neurocognitive Impairment

The authors investigated the combined age and HIV effects on cognitive functions in 146 individuals, 116 of whom had HIV infection. Forty-two percent had HIV-associated neurocognitive disorder, and all were receiving highly active antiretroviral therapy. Using linear and nonlinear regression modelin...

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Bibliographic Details
Published in:The journal of neuropsychiatry and clinical neurosciences 2011-01, Vol.23 (1), p.83-89
Main Authors: Cysique, Lucette A, Maruff, Paul, Bain, Margaret P, Wright, Edwina, Brew, Bruce J
Format: Article
Language:English
Subjects:
Adult
Aged
Aging - psychology
AIDS Dementia Complex - drug therapy
AIDS Dementia Complex - psychology
Antiretroviral Therapy, Highly Active - methods
Biological and medical sciences
Cohort Studies
Female
HIV Infections - drug therapy
HIV Infections - psychology
HIV-1
Human immunodeficiency virus
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Longitudinal Studies
Male
Medical sciences
Middle Aged
Neuropsychological Tests
Prospective Studies
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:The authors investigated the combined age and HIV effects on cognitive functions in 146 individuals, 116 of whom had HIV infection. Forty-two percent had HIV-associated neurocognitive disorder, and all were receiving highly active antiretroviral therapy. Using linear and nonlinear regression modeling, the authors found only a trending effect of the quadratic term HIV status × age, both including dementia cases (p=0.12) and excluding dementia cases (p
ISSN:0895-0172
1545-7222
DOI:10.1176/jnp.23.1.jnp83