Ste20-related kinases: effectors of signaling and morphogenesis in fungi

The family of Ste20-related kinases is conserved from yeast to mammals and includes the p21 activated kinases (PAKs) and germinal centre kinases (GCKs). These kinases have been shown to be involved in signaling through mitogen activated protein kinase (MAPK) pathways and in morphogenesis through the...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 2011-08, Vol.19 (8), p.400-410
Main Authors: Boyce, Kylie J, Andrianopoulos, Alex
Format: Article
Language:English
Subjects:
Actins - metabolism
Cytokinesis
Fungal Proteins - metabolism
Fungi - enzymology
Fungi - genetics
Fungi - growth & development
Fungi - pathogenicity
Gene Expression Regulation, Fungal
hyphae
Hyphae - growth & development
Hyphae - metabolism
Internal Medicine
Intracellular Signaling Peptides and Proteins - metabolism
mammals
MAP Kinase Kinase Kinases
MAP Kinase Signaling System
Microtubules - metabolism
mitogen-activated protein kinase
Morphogenesis
p21-Activated Kinases - metabolism
pathogenesis
Phenotype
Phosphorylation
Phylogeny
Protein-Serine-Threonine Kinases - metabolism
Saccharomyces cerevisiae - enzymology
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - growth & development
Saccharomyces cerevisiae - pathogenicity
Saccharomyces cerevisiae Proteins - metabolism
Sterols - metabolism
Virulence
yeasts
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Summary:The family of Ste20-related kinases is conserved from yeast to mammals and includes the p21 activated kinases (PAKs) and germinal centre kinases (GCKs). These kinases have been shown to be involved in signaling through mitogen activated protein kinase (MAPK) pathways and in morphogenesis through the regulation of cytokinesis and actin-dependent polarized growth. This review concentrates on the role of Ste20-related kinases in fungi where recent research has revealed roles for both PAKs and GCKs in the regulation of cytokinesis and in previously unidentified roles in promoting hyphal growth and differentiation of asexual development structures. In particular, the importance of PAKs during pathogenesis will be examined.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2011.04.006