Development of vaccines against tuberculosis

Summary Development of an effective vaccine against tuberculosis (TB) hinges on an improved understanding of the human immune responses to Mycobacterium tuberculosis . A successful vaccination strategy should be able to stimulate the appropriate arm of the immune system with concomitant generation o...

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Bibliographic Details
Published in:Tuberculosis (Edinburgh, Scotland) Scotland), 2011-09, Vol.91 (5), p.469-478
Main Authors: Tyagi, Anil K, Nangpal, Prachi, Satchidanandam, Vijaya
Format: Article
Language:English
Subjects:
Animals
Antigens, Bacterial - immunology
Disease Models, Animal
Drug Design
Histocompatibility Antigens Class II - immunology
Humans
Immune responses
India
Infectious Disease
Mycobacteria
Mycobacterium tuberculosis
Mycobacterium tuberculosis - immunology
Pulmonary/Respiratory
T-Lymphocytes - immunology
Tuberculosis
Tuberculosis - immunology
Tuberculosis - prevention & control
Tuberculosis Vaccines
Vaccines
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Summary:Summary Development of an effective vaccine against tuberculosis (TB) hinges on an improved understanding of the human immune responses to Mycobacterium tuberculosis . A successful vaccination strategy should be able to stimulate the appropriate arm of the immune system with concomitant generation of the memory cells. In the absence of a perfect strategy, while long term efforts of TB researchers continue to resolve the nature of protective immunity against TB and other related issues, the current approach, dictated by the urgency of a TB vaccine, employs available knowledge and technology to develop new TB vaccines and channel the promising ones to clinical trials. While Indian scientists have contributed in several areas towards the development of a TB vaccine, this review is an attempt to summarize their contributions mainly pertaining to the discovery of new antigens, immune responses elicited by antigens against TB and development of new vaccines and their evaluation in animal models.
ISSN:1472-9792
1873-281X
DOI:10.1016/j.tube.2011.01.003