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Eumycetoma of the Hand Caused by Leptosphaeria tompkinsii and Refractory to Medical Therapy with Voriconazole
We report on the first case of eumycetoma caused by the organism Leptosphaeria tompkinsii to be diagnosed and possibly acquired within the United Kingdom. Conventional culture of fungal grains and surgical tissue specimens was negative and the diagnosis was achieved using panfungal polymerase chain...
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| Published in: | Mycopathologia (1975) 2011-10, Vol.172 (4), p.311-315 |
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| Main Authors: | , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c503t-5ed5356b766c44ab1df7e66406401b50149d74aac84ea682008a4450662f35db3 |
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| cites | cdi_FETCH-LOGICAL-c503t-5ed5356b766c44ab1df7e66406401b50149d74aac84ea682008a4450662f35db3 |
| container_end_page | 315 |
| container_issue | 4 |
| container_start_page | 311 |
| container_title | Mycopathologia (1975) |
| container_volume | 172 |
| creator | Cartwright, Katharine E. Clark, Tristan W. Hussain, Abid M. Wiselka, Martin Borman, Andrew Johnson, Elizabeth M. |
| description | We report on the first case of eumycetoma caused by the organism
Leptosphaeria tompkinsii
to be diagnosed and possibly acquired within the United Kingdom. Conventional culture of fungal grains and surgical tissue specimens was negative and the diagnosis was achieved using panfungal polymerase chain reaction and sequencing technology. Despite limited surgical resection and prolonged antifungal therapy with voriconazole, the patient developed progressive disease with mycetoma bone involvement. This case highlights the usefulness of molecular diagnostic techniques in eumycetoma where organisms may fail to grow with conventional culture or be difficult to identify morphologically. It also reminds us that eumycetoma is a difficult infection to treat and despite optimism regarding the efficacy of the newer triazole antifungals in this condition, treatment failures may still occur. |
| doi_str_mv | 10.1007/s11046-011-9432-8 |
| format | article |
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Leptosphaeria tompkinsii
to be diagnosed and possibly acquired within the United Kingdom. Conventional culture of fungal grains and surgical tissue specimens was negative and the diagnosis was achieved using panfungal polymerase chain reaction and sequencing technology. Despite limited surgical resection and prolonged antifungal therapy with voriconazole, the patient developed progressive disease with mycetoma bone involvement. This case highlights the usefulness of molecular diagnostic techniques in eumycetoma where organisms may fail to grow with conventional culture or be difficult to identify morphologically. It also reminds us that eumycetoma is a difficult infection to treat and despite optimism regarding the efficacy of the newer triazole antifungals in this condition, treatment failures may still occur.</description><identifier>ISSN: 0301-486X</identifier><identifier>EISSN: 1573-0832</identifier><identifier>DOI: 10.1007/s11046-011-9432-8</identifier><identifier>PMID: 21567225</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Antifungal Agents - administration & dosage ; Ascomycota - isolation & purification ; Biomedical and Life Sciences ; Bones ; Debridement ; DNA, Fungal - genetics ; Eukaryotic Microbiology ; Fungi ; Hand - diagnostic imaging ; Hand - microbiology ; Hand - pathology ; Histocytochemistry ; Histopathology ; Humans ; Infections ; Infectious diseases ; Leptosphaeria ; Life Sciences ; Male ; Medical Microbiology ; Microbial Ecology ; Microbiology ; Middle Aged ; Molecular Sequence Data ; Mycetoma - diagnosis ; Mycetoma - microbiology ; Mycetoma - pathology ; Mycetoma - therapy ; Organisms ; Patients ; Plant Sciences ; Polymerase Chain Reaction ; Pyrimidines - administration & dosage ; Sequence Analysis, DNA ; Sinuses ; Tomography, X-Ray Computed ; Treatment Failure ; Triazoles - administration & dosage ; United Kingdom ; Voriconazole</subject><ispartof>Mycopathologia (1975), 2011-10, Vol.172 (4), p.311-315</ispartof><rights>Springer Science+Business Media B.V. 2011</rights><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-5ed5356b766c44ab1df7e66406401b50149d74aac84ea682008a4450662f35db3</citedby><cites>FETCH-LOGICAL-c503t-5ed5356b766c44ab1df7e66406401b50149d74aac84ea682008a4450662f35db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21567225$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cartwright, Katharine E.</creatorcontrib><creatorcontrib>Clark, Tristan W.</creatorcontrib><creatorcontrib>Hussain, Abid M.</creatorcontrib><creatorcontrib>Wiselka, Martin</creatorcontrib><creatorcontrib>Borman, Andrew</creatorcontrib><creatorcontrib>Johnson, Elizabeth M.</creatorcontrib><title>Eumycetoma of the Hand Caused by Leptosphaeria tompkinsii and Refractory to Medical Therapy with Voriconazole</title><title>Mycopathologia (1975)</title><addtitle>Mycopathologia</addtitle><addtitle>Mycopathologia</addtitle><description>We report on the first case of eumycetoma caused by the organism
Leptosphaeria tompkinsii
to be diagnosed and possibly acquired within the United Kingdom. Conventional culture of fungal grains and surgical tissue specimens was negative and the diagnosis was achieved using panfungal polymerase chain reaction and sequencing technology. Despite limited surgical resection and prolonged antifungal therapy with voriconazole, the patient developed progressive disease with mycetoma bone involvement. This case highlights the usefulness of molecular diagnostic techniques in eumycetoma where organisms may fail to grow with conventional culture or be difficult to identify morphologically. 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administration & dosage</topic><topic>Ascomycota - isolation & purification</topic><topic>Biomedical and Life Sciences</topic><topic>Bones</topic><topic>Debridement</topic><topic>DNA, Fungal - genetics</topic><topic>Eukaryotic Microbiology</topic><topic>Fungi</topic><topic>Hand - diagnostic imaging</topic><topic>Hand - microbiology</topic><topic>Hand - pathology</topic><topic>Histocytochemistry</topic><topic>Histopathology</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Leptosphaeria</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Microbial Ecology</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>Mycetoma - diagnosis</topic><topic>Mycetoma - microbiology</topic><topic>Mycetoma - pathology</topic><topic>Mycetoma - therapy</topic><topic>Organisms</topic><topic>Patients</topic><topic>Plant Sciences</topic><topic>Polymerase Chain Reaction</topic><topic>Pyrimidines - 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Academic</collection><jtitle>Mycopathologia (1975)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cartwright, Katharine E.</au><au>Clark, Tristan W.</au><au>Hussain, Abid M.</au><au>Wiselka, Martin</au><au>Borman, Andrew</au><au>Johnson, Elizabeth M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eumycetoma of the Hand Caused by Leptosphaeria tompkinsii and Refractory to Medical Therapy with Voriconazole</atitle><jtitle>Mycopathologia (1975)</jtitle><stitle>Mycopathologia</stitle><addtitle>Mycopathologia</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>172</volume><issue>4</issue><spage>311</spage><epage>315</epage><pages>311-315</pages><issn>0301-486X</issn><eissn>1573-0832</eissn><abstract>We report on the first case of eumycetoma caused by the organism
Leptosphaeria tompkinsii
to be diagnosed and possibly acquired within the United Kingdom. Conventional culture of fungal grains and surgical tissue specimens was negative and the diagnosis was achieved using panfungal polymerase chain reaction and sequencing technology. Despite limited surgical resection and prolonged antifungal therapy with voriconazole, the patient developed progressive disease with mycetoma bone involvement. This case highlights the usefulness of molecular diagnostic techniques in eumycetoma where organisms may fail to grow with conventional culture or be difficult to identify morphologically. It also reminds us that eumycetoma is a difficult infection to treat and despite optimism regarding the efficacy of the newer triazole antifungals in this condition, treatment failures may still occur.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>21567225</pmid><doi>10.1007/s11046-011-9432-8</doi><tpages>5</tpages></addata></record> |
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| subjects | Antifungal Agents - administration & dosage Ascomycota - isolation & purification Biomedical and Life Sciences Bones Debridement DNA, Fungal - genetics Eukaryotic Microbiology Fungi Hand - diagnostic imaging Hand - microbiology Hand - pathology Histocytochemistry Histopathology Humans Infections Infectious diseases Leptosphaeria Life Sciences Male Medical Microbiology Microbial Ecology Microbiology Middle Aged Molecular Sequence Data Mycetoma - diagnosis Mycetoma - microbiology Mycetoma - pathology Mycetoma - therapy Organisms Patients Plant Sciences Polymerase Chain Reaction Pyrimidines - administration & dosage Sequence Analysis, DNA Sinuses Tomography, X-Ray Computed Treatment Failure Triazoles - administration & dosage United Kingdom Voriconazole |
| title | Eumycetoma of the Hand Caused by Leptosphaeria tompkinsii and Refractory to Medical Therapy with Voriconazole |
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