Prognostic impact of c- KIT mutations in core binding factor acute myeloid leukemia

Abstract This study sought to define the prognostic impact of c- KIT mutations in core binding factor acute myeloid leukemia (CBF AML) patients. A total of 116 patients diagnosed as CBF AML in Asan Medical Center from January 1999 to May 2010 were enrolled in this study. We applied melting curve ana...

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Bibliographic Details
Published in:Leukemia research 2011-10, Vol.35 (10), p.1376-1383
Main Authors: Park, Sang Hyuk, Chi, Hyun-Sook, Min, Sook-Kyung, Park, Borae G, Jang, Seongsoo, Park, Chan-Jeoung
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
AML
Bone Marrow - metabolism
Bone Marrow - pathology
c- KIT
Child, Preschool
Chromosome Inversion
Core binding factor
Core Binding Factors - genetics
DNA - analysis
DNA - chemistry
Exons
Female
Hematology, Oncology and Palliative Medicine
Humans
Leukemia, Myeloid, Acute - diagnosis
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - mortality
Leukemia, Myeloid, Acute - pathology
Male
Middle Aged
Mutation
Prognosis
Proto-Oncogene Proteins c-kit - genetics
Retrospective Studies
Sequence Analysis, DNA
Survival Analysis
Transition Temperature
Translocation, Genetic
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Summary:Abstract This study sought to define the prognostic impact of c- KIT mutations in core binding factor acute myeloid leukemia (CBF AML) patients. A total of 116 patients diagnosed as CBF AML in Asan Medical Center from January 1999 to May 2010 were enrolled in this study. We applied melting curve analyses and direct sequencing methods to confirm c- KIT mutations in exon 17 (mut KIT 17) and exon 8 (mut KIT 8). Of the total 116 patients, mut KIT 17 were found in 36 (31%) and mut KIT 8 were found in 7 (6%). In patients with t(8;21), prognosis was significantly poorer in those with mut KIT 17 compared to those without the mutation. This difference was limited to adults. In patients with inv(16), there was no prognostic impact of c- KIT mutations. Therefore, an analysis of mut KIT 17 in adult CBF AML patients with t(8;21) is recommended as a means to predict prognosis.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2011.06.003