Loading…
Comparison of fixator-assisted nailing versus circular external fixator for bone realignment of lower extremity angular deformities in rickets disease
Purpose In rickets patients, limb deformities are usually multiapical and complex even with medical treatment; residual deformities remain necessitating surgical correction. In our study we aim to compare the results of correction of lower limb deformities, in rickets patients, treated with circular...
Saved in:
Published in: | Archives of orthopaedic and trauma surgery 2011-05, Vol.131 (5), p.581-589 |
---|---|
Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c403t-13b315f9e661ad5c735a2016147ac08944c2a527ba06dfeeddb9fe9c77a029b93 |
---|---|
cites | cdi_FETCH-LOGICAL-c403t-13b315f9e661ad5c735a2016147ac08944c2a527ba06dfeeddb9fe9c77a029b93 |
container_end_page | 589 |
container_issue | 5 |
container_start_page | 581 |
container_title | Archives of orthopaedic and trauma surgery |
container_volume | 131 |
creator | Eralp, Levent Kocaoglu, Mehmet Toker, Berkin Balcı, Halil Ibrahim Awad, Ahmed |
description | Purpose
In rickets patients, limb deformities are usually multiapical and complex even with medical treatment; residual deformities remain necessitating surgical correction. In our study we aim to compare the results of correction of lower limb deformities, in rickets patients, treated with circular external fixator versus fixator-assisted intra-medullary nail.
Materials and methods
Seventeen rickets patients, with 39 deformed lower extremity segments (femur and or tibia), underwent deformity correction procedures in our institution. Ten patients with 26 segments were treated using fixator-assisted nailing. Nine patients with 17 segments were treated using Ilizarov technique with circular frame. All patients were evaluated by long-standing true anteroposterior and lateral orthoroentgenograms of lower extremities preoperatively. Joint alignment, joint orientation, and apices of deformities were calculated and noted. The postoperative results of MAD, MPTA, LDFA, PPPTA and functional criteria were compared with preoperative values and assessments made in SPSS 13.0 for Windows by using McNemar, Pearson Chisquare, and Fisher exact statistical tests.
Results
Mean age for the fixator-assisted nailing (FAN) group patients at the time of surgery was 23.8 years (14–37 years). There were 16 femur and 10 tibiae operated on 6 female and 4 male patients. The mean follow up time is 42.6 months (6–71 months). In the Ilizarov group patients the mean age at the time of surgery was 16.7 years (13–22 years). There were 14 tibiae and 3 femur operated on 6 female and 3 male patients. The mean follow-up time was 19 months (6–48 months). Results were evaluated according to the Paley et al. classification of bone and functional results. According to those criteria we had 1 fair, 1 good, and 7 excellent bone results and 1 fair, 1 good, and 7 excellent functional results in the circular ring fixator group. In the FAN group we found 3 good and 7 excellent bone results; 1 fair, 2 good, and 7 excellent functional results. Nearly all patients complained of pain, limping, instability, and walking problems at their first preoperative visit. In both groups there was no union problem; in the FAN group, in one patient correction loss occurred and in another one screw loosening was encountered; in the Ilizarov group, 66% of patients had pin tract infections and one premature fibula consolidation occurred. Statistical analysis revealed no significant difference between two groups in correction |
doi_str_mv | 10.1007/s00402-010-1162-8 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_904480244</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>862604860</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-13b315f9e661ad5c735a2016147ac08944c2a527ba06dfeeddb9fe9c77a029b93</originalsourceid><addsrcrecordid>eNqFkctu1DAUhi0EokPbB2CDLLFgFXp8iWMv0ahcpEpsyjpynJORS2IPPgm0L8Lzkum0ICEhFpZl-_u_I_ln7KWAtwKguSAADbICAZUQRlb2CdsIrXSlnDBP2QacMpWFWpywF0Q3AEJaB8_ZiQQLSjq1YT-3edr7Eiknngc-xFs_51J5okgz9jz5OMa049-x0EI8xBKW0ReOtzOW5MfHBB_W1eWEvKAf4y5NmOaDccw_8B4vOMX5jvu0uxf0uCbWm4jEY-Ilhq84E-8joSc8Y88GPxKeP-yn7Mv7y-vtx-rq84dP23dXVdCg5kqoTol6cGiM8H0dGlV7CcII3fgA1mkdpK9l03kw_YDY950b0IWm8SBd59Qpe3P07kv-tiDN7RQp4Dj6hHmh1oHWFqTW_yWtkQa0NbCSr_8ib_Jy-CtqpTTCWS2UWClxpELJRAWHdl_i5MtdK6A9tNse223hcF7bbe2aefVgXroJ-9-JxzpXQB4BWp_SDsuf0f-2_gIZMLKc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2261984131</pqid></control><display><type>article</type><title>Comparison of fixator-assisted nailing versus circular external fixator for bone realignment of lower extremity angular deformities in rickets disease</title><source>Springer Nature</source><creator>Eralp, Levent ; Kocaoglu, Mehmet ; Toker, Berkin ; Balcı, Halil Ibrahim ; Awad, Ahmed</creator><creatorcontrib>Eralp, Levent ; Kocaoglu, Mehmet ; Toker, Berkin ; Balcı, Halil Ibrahim ; Awad, Ahmed</creatorcontrib><description>Purpose
In rickets patients, limb deformities are usually multiapical and complex even with medical treatment; residual deformities remain necessitating surgical correction. In our study we aim to compare the results of correction of lower limb deformities, in rickets patients, treated with circular external fixator versus fixator-assisted intra-medullary nail.
Materials and methods
Seventeen rickets patients, with 39 deformed lower extremity segments (femur and or tibia), underwent deformity correction procedures in our institution. Ten patients with 26 segments were treated using fixator-assisted nailing. Nine patients with 17 segments were treated using Ilizarov technique with circular frame. All patients were evaluated by long-standing true anteroposterior and lateral orthoroentgenograms of lower extremities preoperatively. Joint alignment, joint orientation, and apices of deformities were calculated and noted. The postoperative results of MAD, MPTA, LDFA, PPPTA and functional criteria were compared with preoperative values and assessments made in SPSS 13.0 for Windows by using McNemar, Pearson Chisquare, and Fisher exact statistical tests.
Results
Mean age for the fixator-assisted nailing (FAN) group patients at the time of surgery was 23.8 years (14–37 years). There were 16 femur and 10 tibiae operated on 6 female and 4 male patients. The mean follow up time is 42.6 months (6–71 months). In the Ilizarov group patients the mean age at the time of surgery was 16.7 years (13–22 years). There were 14 tibiae and 3 femur operated on 6 female and 3 male patients. The mean follow-up time was 19 months (6–48 months). Results were evaluated according to the Paley et al. classification of bone and functional results. According to those criteria we had 1 fair, 1 good, and 7 excellent bone results and 1 fair, 1 good, and 7 excellent functional results in the circular ring fixator group. In the FAN group we found 3 good and 7 excellent bone results; 1 fair, 2 good, and 7 excellent functional results. Nearly all patients complained of pain, limping, instability, and walking problems at their first preoperative visit. In both groups there was no union problem; in the FAN group, in one patient correction loss occurred and in another one screw loosening was encountered; in the Ilizarov group, 66% of patients had pin tract infections and one premature fibula consolidation occurred. Statistical analysis revealed no significant difference between two groups in correction ratios.(pearson chi square
p
= 0.332 for MAD; pearson chi square
p
= 0.477 for LDFA; Paley functional criteria fisher exact
p
= 0.684).
Conclusion
The results indicated that fixator-assisted nailing carries deformity correction accuracy comparable with Ilizarov-type external fixators. FAN provides great patient comfort and the total treatment time is less. In patients with rickets, the retained IM nail can further provide protection against recurrence even if the metabolic pathology reoccurs.</description><identifier>ISSN: 0936-8051</identifier><identifier>EISSN: 1434-3916</identifier><identifier>DOI: 10.1007/s00402-010-1162-8</identifier><identifier>PMID: 20803293</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Adult ; External Fixators ; Female ; Femur - surgery ; Humans ; Ilizarov Technique ; Male ; Medicine ; Medicine & Public Health ; Orthopaedic Surgery ; Orthopedic Procedures - methods ; Orthopedics ; Patients ; Rickets - surgery ; Tibia - surgery ; Treatment Outcome ; Young Adult</subject><ispartof>Archives of orthopaedic and trauma surgery, 2011-05, Vol.131 (5), p.581-589</ispartof><rights>Springer-Verlag 2010</rights><rights>Archives of Orthopaedic and Trauma Surgery is a copyright of Springer, (2010). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-13b315f9e661ad5c735a2016147ac08944c2a527ba06dfeeddb9fe9c77a029b93</citedby><cites>FETCH-LOGICAL-c403t-13b315f9e661ad5c735a2016147ac08944c2a527ba06dfeeddb9fe9c77a029b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20803293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eralp, Levent</creatorcontrib><creatorcontrib>Kocaoglu, Mehmet</creatorcontrib><creatorcontrib>Toker, Berkin</creatorcontrib><creatorcontrib>Balcı, Halil Ibrahim</creatorcontrib><creatorcontrib>Awad, Ahmed</creatorcontrib><title>Comparison of fixator-assisted nailing versus circular external fixator for bone realignment of lower extremity angular deformities in rickets disease</title><title>Archives of orthopaedic and trauma surgery</title><addtitle>Arch Orthop Trauma Surg</addtitle><addtitle>Arch Orthop Trauma Surg</addtitle><description>Purpose
In rickets patients, limb deformities are usually multiapical and complex even with medical treatment; residual deformities remain necessitating surgical correction. In our study we aim to compare the results of correction of lower limb deformities, in rickets patients, treated with circular external fixator versus fixator-assisted intra-medullary nail.
Materials and methods
Seventeen rickets patients, with 39 deformed lower extremity segments (femur and or tibia), underwent deformity correction procedures in our institution. Ten patients with 26 segments were treated using fixator-assisted nailing. Nine patients with 17 segments were treated using Ilizarov technique with circular frame. All patients were evaluated by long-standing true anteroposterior and lateral orthoroentgenograms of lower extremities preoperatively. Joint alignment, joint orientation, and apices of deformities were calculated and noted. The postoperative results of MAD, MPTA, LDFA, PPPTA and functional criteria were compared with preoperative values and assessments made in SPSS 13.0 for Windows by using McNemar, Pearson Chisquare, and Fisher exact statistical tests.
Results
Mean age for the fixator-assisted nailing (FAN) group patients at the time of surgery was 23.8 years (14–37 years). There were 16 femur and 10 tibiae operated on 6 female and 4 male patients. The mean follow up time is 42.6 months (6–71 months). In the Ilizarov group patients the mean age at the time of surgery was 16.7 years (13–22 years). There were 14 tibiae and 3 femur operated on 6 female and 3 male patients. The mean follow-up time was 19 months (6–48 months). Results were evaluated according to the Paley et al. classification of bone and functional results. According to those criteria we had 1 fair, 1 good, and 7 excellent bone results and 1 fair, 1 good, and 7 excellent functional results in the circular ring fixator group. In the FAN group we found 3 good and 7 excellent bone results; 1 fair, 2 good, and 7 excellent functional results. Nearly all patients complained of pain, limping, instability, and walking problems at their first preoperative visit. In both groups there was no union problem; in the FAN group, in one patient correction loss occurred and in another one screw loosening was encountered; in the Ilizarov group, 66% of patients had pin tract infections and one premature fibula consolidation occurred. Statistical analysis revealed no significant difference between two groups in correction ratios.(pearson chi square
p
= 0.332 for MAD; pearson chi square
p
= 0.477 for LDFA; Paley functional criteria fisher exact
p
= 0.684).
Conclusion
The results indicated that fixator-assisted nailing carries deformity correction accuracy comparable with Ilizarov-type external fixators. FAN provides great patient comfort and the total treatment time is less. In patients with rickets, the retained IM nail can further provide protection against recurrence even if the metabolic pathology reoccurs.</description><subject>Adolescent</subject><subject>Adult</subject><subject>External Fixators</subject><subject>Female</subject><subject>Femur - surgery</subject><subject>Humans</subject><subject>Ilizarov Technique</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Orthopaedic Surgery</subject><subject>Orthopedic Procedures - methods</subject><subject>Orthopedics</subject><subject>Patients</subject><subject>Rickets - surgery</subject><subject>Tibia - surgery</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0936-8051</issn><issn>1434-3916</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkctu1DAUhi0EokPbB2CDLLFgFXp8iWMv0ahcpEpsyjpynJORS2IPPgm0L8Lzkum0ICEhFpZl-_u_I_ln7KWAtwKguSAADbICAZUQRlb2CdsIrXSlnDBP2QacMpWFWpywF0Q3AEJaB8_ZiQQLSjq1YT-3edr7Eiknngc-xFs_51J5okgz9jz5OMa049-x0EI8xBKW0ReOtzOW5MfHBB_W1eWEvKAf4y5NmOaDccw_8B4vOMX5jvu0uxf0uCbWm4jEY-Ilhq84E-8joSc8Y88GPxKeP-yn7Mv7y-vtx-rq84dP23dXVdCg5kqoTol6cGiM8H0dGlV7CcII3fgA1mkdpK9l03kw_YDY950b0IWm8SBd59Qpe3P07kv-tiDN7RQp4Dj6hHmh1oHWFqTW_yWtkQa0NbCSr_8ib_Jy-CtqpTTCWS2UWClxpELJRAWHdl_i5MtdK6A9tNse223hcF7bbe2aefVgXroJ-9-JxzpXQB4BWp_SDsuf0f-2_gIZMLKc</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Eralp, Levent</creator><creator>Kocaoglu, Mehmet</creator><creator>Toker, Berkin</creator><creator>Balcı, Halil Ibrahim</creator><creator>Awad, Ahmed</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>20110501</creationdate><title>Comparison of fixator-assisted nailing versus circular external fixator for bone realignment of lower extremity angular deformities in rickets disease</title><author>Eralp, Levent ; Kocaoglu, Mehmet ; Toker, Berkin ; Balcı, Halil Ibrahim ; Awad, Ahmed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-13b315f9e661ad5c735a2016147ac08944c2a527ba06dfeeddb9fe9c77a029b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>External Fixators</topic><topic>Female</topic><topic>Femur - surgery</topic><topic>Humans</topic><topic>Ilizarov Technique</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Orthopaedic Surgery</topic><topic>Orthopedic Procedures - methods</topic><topic>Orthopedics</topic><topic>Patients</topic><topic>Rickets - surgery</topic><topic>Tibia - surgery</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eralp, Levent</creatorcontrib><creatorcontrib>Kocaoglu, Mehmet</creatorcontrib><creatorcontrib>Toker, Berkin</creatorcontrib><creatorcontrib>Balcı, Halil Ibrahim</creatorcontrib><creatorcontrib>Awad, Ahmed</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Archives of orthopaedic and trauma surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eralp, Levent</au><au>Kocaoglu, Mehmet</au><au>Toker, Berkin</au><au>Balcı, Halil Ibrahim</au><au>Awad, Ahmed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of fixator-assisted nailing versus circular external fixator for bone realignment of lower extremity angular deformities in rickets disease</atitle><jtitle>Archives of orthopaedic and trauma surgery</jtitle><stitle>Arch Orthop Trauma Surg</stitle><addtitle>Arch Orthop Trauma Surg</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>131</volume><issue>5</issue><spage>581</spage><epage>589</epage><pages>581-589</pages><issn>0936-8051</issn><eissn>1434-3916</eissn><abstract>Purpose
In rickets patients, limb deformities are usually multiapical and complex even with medical treatment; residual deformities remain necessitating surgical correction. In our study we aim to compare the results of correction of lower limb deformities, in rickets patients, treated with circular external fixator versus fixator-assisted intra-medullary nail.
Materials and methods
Seventeen rickets patients, with 39 deformed lower extremity segments (femur and or tibia), underwent deformity correction procedures in our institution. Ten patients with 26 segments were treated using fixator-assisted nailing. Nine patients with 17 segments were treated using Ilizarov technique with circular frame. All patients were evaluated by long-standing true anteroposterior and lateral orthoroentgenograms of lower extremities preoperatively. Joint alignment, joint orientation, and apices of deformities were calculated and noted. The postoperative results of MAD, MPTA, LDFA, PPPTA and functional criteria were compared with preoperative values and assessments made in SPSS 13.0 for Windows by using McNemar, Pearson Chisquare, and Fisher exact statistical tests.
Results
Mean age for the fixator-assisted nailing (FAN) group patients at the time of surgery was 23.8 years (14–37 years). There were 16 femur and 10 tibiae operated on 6 female and 4 male patients. The mean follow up time is 42.6 months (6–71 months). In the Ilizarov group patients the mean age at the time of surgery was 16.7 years (13–22 years). There were 14 tibiae and 3 femur operated on 6 female and 3 male patients. The mean follow-up time was 19 months (6–48 months). Results were evaluated according to the Paley et al. classification of bone and functional results. According to those criteria we had 1 fair, 1 good, and 7 excellent bone results and 1 fair, 1 good, and 7 excellent functional results in the circular ring fixator group. In the FAN group we found 3 good and 7 excellent bone results; 1 fair, 2 good, and 7 excellent functional results. Nearly all patients complained of pain, limping, instability, and walking problems at their first preoperative visit. In both groups there was no union problem; in the FAN group, in one patient correction loss occurred and in another one screw loosening was encountered; in the Ilizarov group, 66% of patients had pin tract infections and one premature fibula consolidation occurred. Statistical analysis revealed no significant difference between two groups in correction ratios.(pearson chi square
p
= 0.332 for MAD; pearson chi square
p
= 0.477 for LDFA; Paley functional criteria fisher exact
p
= 0.684).
Conclusion
The results indicated that fixator-assisted nailing carries deformity correction accuracy comparable with Ilizarov-type external fixators. FAN provides great patient comfort and the total treatment time is less. In patients with rickets, the retained IM nail can further provide protection against recurrence even if the metabolic pathology reoccurs.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>20803293</pmid><doi>10.1007/s00402-010-1162-8</doi><tpages>9</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0936-8051 |
ispartof | Archives of orthopaedic and trauma surgery, 2011-05, Vol.131 (5), p.581-589 |
issn | 0936-8051 1434-3916 |
language | eng |
recordid | cdi_proquest_miscellaneous_904480244 |
source | Springer Nature |
subjects | Adolescent Adult External Fixators Female Femur - surgery Humans Ilizarov Technique Male Medicine Medicine & Public Health Orthopaedic Surgery Orthopedic Procedures - methods Orthopedics Patients Rickets - surgery Tibia - surgery Treatment Outcome Young Adult |
title | Comparison of fixator-assisted nailing versus circular external fixator for bone realignment of lower extremity angular deformities in rickets disease |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T02%3A24%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20fixator-assisted%20nailing%20versus%20circular%20external%20fixator%20for%20bone%20realignment%20of%20lower%20extremity%20angular%20deformities%20in%20rickets%20disease&rft.jtitle=Archives%20of%20orthopaedic%20and%20trauma%20surgery&rft.au=Eralp,%20Levent&rft.date=2011-05-01&rft.volume=131&rft.issue=5&rft.spage=581&rft.epage=589&rft.pages=581-589&rft.issn=0936-8051&rft.eissn=1434-3916&rft_id=info:doi/10.1007/s00402-010-1162-8&rft_dat=%3Cproquest_cross%3E862604860%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c403t-13b315f9e661ad5c735a2016147ac08944c2a527ba06dfeeddb9fe9c77a029b93%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2261984131&rft_id=info:pmid/20803293&rfr_iscdi=true |