Isopimarane diterpene glycosides, isolated from endophytic fungus Paraconiothyrium sp. MY-42

Isopimarane diterpene glycosides showed moderate cytotoxicities against the human promyelocytic leukemia cell line HL60 with Ic50 values of 6.7 and 9.8μM for two of these compounds. [Display omitted] ► Isopimarane diterpenes were isolated from endophytic fungus Pleosporales sp. ► The structures of d...

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Published in:Phytochemistry (Oxford) 2011-08, Vol.72 (11-12), p.1400-1405
Main Authors: Shiono, Yoshihito, Kikuchi, Miwako, Koseki, Takuya, Murayama, Tetsuya, Kwon, Eunsang, Aburai, Nobuhiro, Kimura, Ken-ichi
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Ascomycota - chemistry
Biological and medical sciences
Chemical constitution
Chemical Fractionation - methods
Crystallography, X-Ray
Cytotoxicity
Diterpenes - chemistry
Diterpenes - isolation & purification
diterpenoids
endophytes
Endophytic fungus
Fermentation
Fundamental and applied biological sciences. Psychology
fungi
Glucosamine - chemistry
glycosides
Glycosides - chemistry
Glycosides - isolation & purification
HL-60 Cells
Humans
Inhibitory Concentration 50
Isopimarane diterpenes
leukemia
Magnetic Resonance Spectroscopy
Molecular Structure
Optical Rotation
Paraconiothyrium sp
Plant physiology and development
spectroscopy
Stereoisomerism
X-ray diffraction
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Summary:Isopimarane diterpene glycosides showed moderate cytotoxicities against the human promyelocytic leukemia cell line HL60 with Ic50 values of 6.7 and 9.8μM for two of these compounds. [Display omitted] ► Isopimarane diterpenes were isolated from endophytic fungus Pleosporales sp. ► The structures of diterpenes were determined by NMR and MS studies. ► All compounds were evaluated for cytotoxicity. ► Compounds 2 and 3 showed moderate cytotoxicities against HL60 cells. Six isopimarane diterpenes, compounds 1–6, were isolated from the endophytic fungus Paraconiothyrium sp. MY-42. Compound 1 possesses a 19-glucopyranosyloxy group. Its structure was first elucidated by spectroscopic data analysis and finally confirmed by X-ray crystallography, whereas structures 2–6 were mainly elucidated based on the analysis of spectroscopic evidence. Compounds 2 and 3 showed moderate cytotoxicities against the human promyelocytic leukemia cell line HL60 (IC50 6.7μM value for 2 and 9.8μM for 3).
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2011.04.016