Histone modifications in transcriptional activation during plant development

In eukaryotic cell nuclei, chromatin states dictated by different combinations of post-translational modifications of histones, such as acetylation, methylation and monoubiquitination of lysine residues, are part of the multitude of epigenomes involved in the fine-tuning of all genetic functions and...

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Published in:Biochimica et biophysica acta 2011-10, Vol.1809 (10), p.567-576
Main Authors: Berr, Alexandre, Shafiq, Sarfraz, Shen, Wen-Hui
Format: Article
Language:English
Subjects:
Arabidopsis
Arabidopsis - genetics
Arabidopsis - metabolism
Arabidopsis Proteins - metabolism
Arabidopsis thaliana
Biochemistry, Molecular Biology
Cellular Biology
Chromatin - metabolism
Epigenesis, Genetic
Epigenetic regulation
FLC transcription
Gene Expression Regulation, Plant
Histone acetylation
Histone methylation
Histone monoubiquitination
Histones - metabolism
Life Sciences
Methylation
Molecular biology
Plants - genetics
Plants - metabolism
RNA Polymerase II - metabolism
Transcriptional Activation
Ubiquitin - metabolism
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Summary:In eukaryotic cell nuclei, chromatin states dictated by different combinations of post-translational modifications of histones, such as acetylation, methylation and monoubiquitination of lysine residues, are part of the multitude of epigenomes involved in the fine-tuning of all genetic functions and in particular transcription. During the past decade, an increasing number of ‘writers’, ‘readers’ and ‘erasers’ of histone modifications have been identified. Characterization of these factors in Arabidopsis has unraveled their pivotal roles in the regulation of essential processes, such as floral transition, cell differentiation, gametogenesis, and plant response/adaptation to environmental stresses. In this review we focus on histone modification marks associated with transcriptional activation to highlight current knowledge on Arabidopsis ‘writers’, ‘readers’ and ‘erasers’ of histone modifications and to discuss recent findings on molecular mechanisms of integration of histone modifications with the RNA polymerase II transcriptional machinery during transcription of the flowering repressor gene FLC. ► Histone post-translational modifications (PTMs) involved in transcriptional activation. ► ‘Writers’, ‘readers’ and ‘erasers’ of histone PTMs. ► Histone PTMs during FLC transcription activation, initiation and elongation processes.
ISSN:1874-9399
0006-3002
1876-4320
DOI:10.1016/j.bbagrm.2011.07.001