Poly(ADP-ribose) polymerase-1 mRNA expression in human breast cancer: a meta-analysis

Although poly(ADP-ribose) polymerase-1 (PARP1) inhibition is a recent promising therapy in breast cancer, PARP1 expression in this disease is not known. Using DNA microarray and array-based comparative genomic hybridization (arrayCGH), we examined PARP1 mRNA expression and copy number alterations in...

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Bibliographic Details
Published in:Breast cancer research and treatment 2011-05, Vol.127 (1), p.273-281
Main Authors: Gonçalves, Anthony, Finetti, Pascal, Sabatier, Renaud, Gilabert, Marine, Adelaide, José, Borg, Jean-Paul, Chaffanet, Max, Viens, Patrice, Birnbaum, Daniel, Bertucci, François
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Breast cancer
Breast Neoplasms - genetics
Brief Report
Cancer
Cancer research
Cancer therapies
Chemotherapy
Comparative analysis
Cytogenetics
Development and progression
DNA
DNA Copy Number Variations - genetics
DNA microarrays
Female
Gene expression
Gene Expression Profiling
Genes
Genetics
Gynecology. Andrology. Obstetrics
Health aspects
Humans
Mammary gland diseases
Medical prognosis
Medical sciences
Medicine
Medicine & Public Health
Messenger RNA
Meta-analysis
Middle Aged
Monosaccharides
Oncology
Poly(ADP-ribose) Polymerases - genetics
Poly(ADP-ribose) Polymerases - metabolism
RNA, Messenger - metabolism
Sugars
Survival Analysis
Tumors
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Summary:Although poly(ADP-ribose) polymerase-1 (PARP1) inhibition is a recent promising therapy in breast cancer, PARP1 expression in this disease is not known. Using DNA microarray and array-based comparative genomic hybridization (arrayCGH), we examined PARP1 mRNA expression and copy number alterations in 326 invasive breast cancer samples and normal breast (NB) samples. A meta-analysis was performed on a large public retrospective gene expression data set ( n  = 2,485) to analyze correlation between PARP1 mRNA expression and molecular subtypes and clinico-pathological parameters. PARP1 was overexpressed in 58% of cancers, and its expression was heterogeneous between tumors. ArrayCGH data revealed an association between mRNA overexpression and gain/amplification at the PARP1 locus ( P  
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-010-1199-y