miRNA and nasopharyngeal carcinoma

MicroRNAs (miRNAs) constitute a family of small non-coding RNA molecules 22–25 nucleotides in length. miRNAs control the expression of target genes at the post-transcriptional level by inhibiting translation or by degrading target mRNA through binding to complementary sequences in the 3′-untranslate...

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Bibliographic Details
Published in:Chinese science bulletin 2011-03, Vol.56 (8), p.722-728
Main Authors: Zhao, LuQing, Chen, Xue, Cao, Ya
Format: Article
Language:English
Subjects:
3' Untranslated regions
carcinoma
Chemistry/Food Science
Earth Sciences
Engineering
genes
Humanities and Social Sciences
Life Sciences
membrane proteins
messenger RNA
microRNA
miRNAs
mitosis
multidisciplinary
nucleotides
Physics
Review
Science
Science (multidisciplinary)
signal transduction
translation (genetics)
信号转导通路
基因调控网络
小分子RNA
潜伏膜蛋白1
肿瘤血管生成
非编码RNA
鼻咽癌
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Summary:MicroRNAs (miRNAs) constitute a family of small non-coding RNA molecules 22–25 nucleotides in length. miRNAs control the expression of target genes at the post-transcriptional level by inhibiting translation or by degrading target mRNA through binding to complementary sequences in the 3′-untranslated regions. Recent studies have demonstrated that miRNAs are intimately involved in processes leading to nasopharyngeal carcinoma, such as the Epstein-Barr virus-encoded latent membrane protein 1 activated signal transduction pathways, gene-regulatory networks, mitosis, tumor angiogenesis, invasion and migration. Exploring the relationship between miRNAs and the development of nasopharyngeal carcinoma, will further the understanding of this cancer and provide new avenues for diagnosis and treatment.
ISSN:1001-6538
1861-9541
DOI:10.1007/s11434-010-4330-x