Preservative of choice for Prev(e)nar 13™ in a multi-dose formulation

Highlights ► Antimicrobial effectiveness of various preservatives for preparation of Prev(e)nar 13™ multi-dose formulation was evaluated. ► Both single challenge method, recommended by various compendia, and WHO-recommended multi-challenge criteria were used for these evaluations. ► The ideal preser...

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Bibliographic Details
Published in:Vaccine 2011-09, Vol.29 (41), p.7144-7153
Main Authors: Khandke, Lakshmi, Yang, Cindy, Krylova, Ksenia, Jansen, Kathrin U, Rashidbaigi, Abbas
Format: Article
Language:English
Subjects:
2-Phenoxyethanol
Allergy and Immunology
Anti-Bacterial Agents - pharmacology
anti-infective properties
Applied microbiology
Biological and medical sciences
Chemistry, Pharmaceutical
Developing countries
Drug Storage
Ear diseases
Effectiveness
Ethylene Glycols - pharmacology
Fundamental and applied biological sciences. Psychology
growth retardation
Humans
Immunization
issues and policy
LDCs
Methods
Microbiology
Microorganisms
Multi-dose
Pneumococcal Vaccines - chemistry
Pneumococcal Vaccines - immunology
Preservatives
Preservatives, Pharmaceutical - pharmacology
Staphylococcus aureus
Staphylococcus aureus - drug effects
Streptococcus infections
Streptococcus pneumoniae
Studies
thimerosal
Thimerosal - pharmacology
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
World Health Organization
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Description
Summary:Highlights ► Antimicrobial effectiveness of various preservatives for preparation of Prev(e)nar 13™ multi-dose formulation was evaluated. ► Both single challenge method, recommended by various compendia, and WHO-recommended multi-challenge criteria were used for these evaluations. ► The ideal preservative was 2-Phenoxyethanol at 5 mg/dose.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.05.074