Chronic liver disease increases the risk of linezolid-related thrombocytopenia in methicillin-resistant Staphylococcus aureus -infected patients after digestive surgery

Abstract Linezolid is an effective antibiotic for treatment of infections caused by resistant Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). However, thrombocytopenia has been reported in a certain proportion of patients receiving linezolid treatment. We invest...

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Bibliographic Details
Published in:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2011-06, Vol.17 (3), p.388-391
Main Authors: Ikuta, Shin-ichi, Yasui, Chiaki, Aihara, Tsukasa, Yoshie, Hidenori, Iida, Hiroya, Beppu, Naohito, Kurimoto, Ami, Yanagi, Hidenori, Mitsunobu, Masao, Yamanaka, Naoki, Tanimura, Kiyoko
Format: Article
Language:English
Subjects:
Acetamides - adverse effects
Acetamides - therapeutic use
Aged
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - therapeutic use
Chronic liver disease
Female
Hematology, Oncology and Palliative Medicine
Humans
Infectious Diseases
Linezolid
Liver Diseases - blood
Liver Diseases - complications
Liver Diseases - microbiology
Male
Medical Microbiology
Medicine
Medicine & Public Health
Methicillin-resistant Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Middle Aged
Multivariate Analysis
Original Article
Oxazolidinones - adverse effects
Oxazolidinones - therapeutic use
Platelet Count - methods
Risk Factors
Staphylococcal Infections - blood
Staphylococcal Infections - complications
Staphylococcus aureus
Thrombocytopenia
Thrombocytopenia - blood
Thrombocytopenia - chemically induced
Thrombocytopenia - etiology
Thrombocytopenia - microbiology
Virology
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Summary:Abstract Linezolid is an effective antibiotic for treatment of infections caused by resistant Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). However, thrombocytopenia has been reported in a certain proportion of patients receiving linezolid treatment. We investigated the risk factors for linezolid-related thrombocytopenia in MRSA-infected patients after digestive surgery. Forty-three patients who were treated with linezolid for postoperative MRSA infection were enrolled. We compared the characteristics of the patients who developed thrombocytopenia during linezolid therapy with those of the patients who did not. Thrombocytopenia was defined as a platelet ratio (post/pre-treatment with linezolid) of
ISSN:1341-321X
1437-7780
DOI:10.1007/s10156-010-0188-8