Antibacterial, antifungal, antiherbicidal, and antifungicidal activity of 4,6-dimethoxyhomophthalic acid and related compounds

4,6-Dimethoxyhomophthalic acid ( 5 ) has been synthesized efficiently in four steps from 3,5-dimethoxycinnamic acid ( 1 ) and characterized and screened for their in vitro antibacterial activity against four Gram negative ( Escherichia coli, Pseudomonas aeruginosa, Salmonella typhii, and Shigella fl...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2008-06, Vol.42 (6), p.335-339, Article 335
Main Authors: Qadeer, Ghulam, Rama, Nasim Hasan, Zareef, Muhammad, Al-Masoudi, Najim A.
Format: Article
Language:English
Subjects:
Aspergillus flavus
Bacillus subtilis
Candida albicans
Escherichia coli
Fusarium solani
Medicine
Microsporum canis
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Pseudomonas aeruginosa
Salmonella
Shigella flexneri
Staphylococcus aureus
The Search for New Therapeutic Substances
Trichophyton
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Summary:4,6-Dimethoxyhomophthalic acid ( 5 ) has been synthesized efficiently in four steps from 3,5-dimethoxycinnamic acid ( 1 ) and characterized and screened for their in vitro antibacterial activity against four Gram negative ( Escherichia coli, Pseudomonas aeruginosa, Salmonella typhii, and Shigella flexneri ) and two Gram-positive ( Bacillus subtilis and Staphylococcus aureus ) bacterial strains, and for in vitro antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani, and Candida glaberata . The compounds were screened for their in vitro antiherbicidal and antifungicidal activities.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-008-0121-y